Kenneth L. Audus

TL;DR: The results indicated that the A549 cell line may be useful for the studying the metabolic and macromolecule processing contributions of alveolar Type II cells to mechanisms of drug delivery at the pulmonary epithelium.

TL;DR: Tie-1 and tie-2 may form another class within the receptor tyrosine kinase gene family, and further characterization of these genes and identification of their putative ligands should define the nature of the signal-transduction cascades underlying early vascular system development, as well as their differential roles in mesodermal cells of the amniotic and myeloid lineages.

TL;DR: The range of in vitro cell-based BBB models available are reviewed, including the primary/low passage bovine and porcine brain endothelial cultures as well as the spectrum of immortalizedbrain endothelial cell lines that have been established, to discuss the benefits and limitations of exploiting such systems as in vitro BBB permeability screens.

TL;DR: Some of the general factors that should be considered in developing a cell culture model for transport studies and metabolism studies are described.

TL;DR: It is demonstrated that cultures of hepatocytes maintained in a sandwich configuration may serve as a more reliable and representative model in which to study the physiology of hepatic function as well as the morphogenesis of polarized membrane domains in vitro.