Larry J. Prokop

TL;DR: The risk of liver‐related mortality increases exponentially with increase in fibrosis stage; these data have important implications in assessing the utility of each stage and benefits of regression of fibrosis from one stage to another.

TL;DR: Based on a meta-analysis of studies of paired liver biopsy studies, liver fibrosis progresses in patients with NAFL and NASH.

TL;DR: A history of sexual abuse is associated with an increased risk of a lifetime diagnosis of multiple psychiatric disorders and associations between sexual abuse and depression, eating disorders, and posttraumatic stress disorder were strengthened by a history of rape.

TL;DR: All active agents were associated with significant excess weight loss compared with placebo at 1 year and phentermine-topiramate, naltrexone-bupropion, and liraglutide, each associated with 5% weight loss at 52 weeks, were linked with the highest odds of adverse event-related treatment discontinuation.

TL;DR: Evidence suggests a history of sexual abuse is associated with lifetime diagnosis of multiple somatic disorders.