L
Laura J. den Hartigh
Researcher at University of Washington
Publications - 33
Citations - 1578
Laura J. den Hartigh is an academic researcher from University of Washington. The author has contributed to research in topics: Adipose tissue & Inflammation. The author has an hindex of 15, co-authored 27 publications receiving 944 citations. Previous affiliations of Laura J. den Hartigh include University of California, Davis.
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Journal ArticleDOI
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.
Alan Chait,Laura J. den Hartigh +1 more
TL;DR: The mechanisms by which dysfunctional adipose tissue simultaneously promote T2DM and CVD, focusing on adipose tissues depot-specific adipokines, inflammatory profiles, and metabolism, will be the focus of this review.
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Conjugated linoleic acid effects on cancer, obesity, and atherosclerosis: A review of pre-clinical and human trials with current perspectives
TL;DR: The potential mechanisms for the many integrative physiological effects of CLA supplementation will be discussed in detail, including an introduction to the gut microbiota as a potential mediator of CLA effects on obesity and atherosclerosis.
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NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes.
Chang Yeop Han,Tomio Umemoto,Mohamed Omer,Laura J. den Hartigh,Tsuyoshi Chiba,Renee C. LeBoeuf,Carolyn L. Buller,Ian R. Sweet,Subramaniam Pennathur,E. Dale Abel,Alan Chait +10 more
TL;DR: Understanding the source of ROS generation may lead to the development of new therapeutic targets for adipose tissue inflammation, and both high glucose and palmitate induced NOX4 translocation into lipid rafts, effects that were blocked by DHA.
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Apolipoprotein AI and High-Density Lipoprotein Have Anti-Inflammatory Effects on Adipocytes via Cholesterol Transporters ATP-Binding Cassette A-1, ATP-Binding Cassette G-1, and Scavenger Receptor B-1
Tomio Umemoto,Chang Yeop Han,Poulami Mitra,Michelle M. Averill,Chongren Tang,Leela Goodspeed,Mohamed Omer,Savitha Subramanian,Shari Wang,Laura J. den Hartigh,Hao Wei,Eung Ju Kim,Jinkyu Kim,Kevin D. O’Brien,Alan Chait +14 more
TL;DR: ApoAI and HDL have anti-inflammatory effects in adipocytes and adipose tissue similar to their effects in other cell types, and these effects are consistent with disruption and removal of cholesterol from LRs, which are regulated by cholesterol transporters.
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Fatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes
Laura J. den Hartigh,Jaime E. Connolly-Rohrbach,Samantha Fore,Thomas R Huser,John C. Rutledge +4 more
TL;DR: In this paper, the authors examined post-prandial monocyte activation in more detail, and found that lipolysis products generated from post-andial VLDL induce the formation of lipidfilled droplets within cultured THP-1 monocytes, characterized by coherent antistokes Raman spectroscopy.