L
Lauren M. Aleksunes
Researcher at Rutgers University
Publications - 153
Citations - 7278
Lauren M. Aleksunes is an academic researcher from Rutgers University. The author has contributed to research in topics: Efflux & Kidney. The author has an hindex of 44, co-authored 137 publications receiving 6277 citations. Previous affiliations of Lauren M. Aleksunes include University of Kansas & University of Connecticut.
Papers
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Journal ArticleDOI
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation
TL;DR: A comprehensive overview of transporters of the solute carrier family (SLC) is provided with regard to tissue distribution, subcellular localization, and substrate preferences.
Journal ArticleDOI
Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway
Jonathan M. Maher,Matthew Z. Dieter,Lauren M. Aleksunes,Angela L. Slitt,Angela L. Slitt,Grace L. Guo,Yuji Tanaka,George L. Scheffer,Jefferson Y. Chan,José E. Manautou,Ying Chen,Timothy P. Dalton,Masayuki Yamamoto,Curtis D. Klaassen +13 more
TL;DR: The activation of the Nrf2 regulatory pathway stimulates the coordinated induction of hepatic Mrps in mice treated with oltipraz and butylated hydroxyanisole.
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Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease
TL;DR: Research of Nrf2 has opened up new opportunities in understanding how antioxidant defense pathways are regulated, how oxidative stress contributes to disease progression and may serve as a novel target for designing therapies to prevent and treat diseases in which oxidative stress is implicated.
Journal ArticleDOI
Introducing the "TCDD-inducible AhR-Nrf2 gene battery".
TL;DR: The present study demonstrates the novel finding that Nrf2 is required for TCDD induction of classical AhR battery genes Nqo1, Ugt1a6, and Gsta1, as well as most Ugt and Gst isoforms in livers of mice.
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Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
TL;DR: Identification of genes encoding drug-metabolizing enzymes and transporters altered by chemical activators in a transcription factor-dependent manner and Pharmacological activation of each transcription factor leads to mRNA induction of drug metabolic and transport genes in livers of male and female wild-type mice reveal transcription factor specificity and overlap in regulating hepatic drug disposition genes by chemical activation.