L
Lee Josephson
Researcher at Harvard University
Publications - 253
Citations - 23540
Lee Josephson is an academic researcher from Harvard University. The author has contributed to research in topics: Magnetic nanoparticles & Receptor-mediated endocytosis. The author has an hindex of 77, co-authored 248 publications receiving 22588 citations. Previous affiliations of Lee Josephson include University of Pennsylvania & ETH Zurich.
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Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
TL;DR: An ultrasmall superparamagnetic iron oxide preparation was developed that is small enough to migrate across the capillary wall, a prerequisite in the design of targetable particulate pharmaceuticals.
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High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.
TL;DR: A biocompatible, dextran coated superparamagnetic iron oxide particle was derivatized with a peptide sequence from the HIV-tat protein to improve intracellular magnetic labeling of different target cells, and internalized into lymphocytes over 100-fold more efficiently than nonmodified particles.
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Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
TL;DR: Whether multivalent attachment of small molecules can increase specific binding affinity and reveal new biological properties of nanomaterials is investigated and a parallel synthesis of a library comprising 146 nanoparticles decorated with different synthetic small molecules is described.
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Magnetic relaxation switches capable of sensing molecular interactions
TL;DR: Biocompatible magnetic nanosensors that act as magnetic relaxation switches (MRS) to detect molecular interactions in the reversible self-assembly of disperse magnetic particles into stable nanoassemblies are developed.
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Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
TL;DR: A potent (Na,K)-ATPase inhibitor purified from "Sigma Grade* ATP" has been identified as vanadium using electron probe microanalysis and confirmed by microwave-induced emission spectroscopy and electron paramagnetic resonanceSpectroscopy.