L
Leon W.M.M. Terstappen
Researcher at University of Twente
Publications - 293
Citations - 29976
Leon W.M.M. Terstappen is an academic researcher from University of Twente. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 70, co-authored 284 publications receiving 27728 citations. Previous affiliations of Leon W.M.M. Terstappen include Wilmington University & Case Western Reserve University.
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Journal ArticleDOI
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Massimo Cristofanilli,G. Thomas Budd,Matthew J. Ellis,Alison Stopeck,Jeri Matera,M. Craig Miller,James M. Reuben,Gerald V. Doyle,W. Jeffrey Allard,Leon W.M.M. Terstappen,Daniel F. Hayes +10 more
TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
Journal ArticleDOI
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases.
W. Jeffrey Allard,Jeri Matera,M. Craig Miller,Madeline Repollet,Mark Connelly,Chandra Rao,Arjan G.J. Tibbe,Jonathan W. Uhr,Leon W.M.M. Terstappen +8 more
TL;DR: The CellSearch system can be standardized across multiple laboratories and may be used to determine the clinical utility of CTCs, which are extremely rare in healthy subjects and patients with nonmalignant diseases but present in various metastatic carcinomas with a wide range of frequencies.
Journal ArticleDOI
Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer
Steven J. Cohen,Cornelis J A Punt,Nicholas Iannotti,B. H. Saidman,Kert D. Sabbath,Nashat Y. Gabrail,Joel Picus,Michael A. Morse,Edith P. Mitchell,M. Craig Miller,Gerald V. Doyle,H. Tissing,Leon W.M.M. Terstappen,Neal J. Meropol +13 more
TL;DR: The number of CTCs before and during treatment is an independent predictor of PFS and OS in patients with metastatic colorectal cancer and Baseline and follow-up CTC levels remained strong predictors of P FS and OS after adjustment for clinically significant factors.
Journal ArticleDOI
Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer
Massimo Cristofanilli,Daniel F. Hayes,G. Thomas Budd,Mathew J. Ellis,A. Stopeck,James M. Reuben,Gerald V. Doyle,Jeri Matera,W. Jeffrey Allard,M. Craig Miller,Herbert A. Fritsche,Gabriel N. Hortobagyi,Leon W.M.M. Terstappen +12 more
TL;DR: In this article, the authors investigated whether the presence of circulating tumor cells (CTCs) predicts treatment efficacy, progression-free survival (PFS), and overall survival (OS) in patients with newly diagnosed metastatic breast cancer who were about to start first-line therapy.
Journal ArticleDOI
Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells.
TL;DR: Direct evidence is provided for the existence of a single class of progenitors with extensive proliferative capacity in human BM and an experimental approach for their purification, manipulation, and further characterization is provided.