L
Lloyd J. Old
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 775
Citations - 106937
Lloyd J. Old is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 152, co-authored 775 publications receiving 101377 citations. Previous affiliations of Lloyd J. Old include Rockefeller University & Cornell University.
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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
TL;DR: A unifying conceptual framework called “cancer immunoediting,” which integrates the immune system’s dual host-protective and tumor-promoting roles is discussed.
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Cancer immunoediting: from immunosurveillance to tumor escape.
TL;DR: The historical and experimental basis of cancer immunoediting is summarized and its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction are discussed.
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An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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IFNγ, and lymphocytes prevent primary tumour development and shape tumour immunogenicity
Vijay Shankaran,Hiroaki Ikeda,Allen T. Bruce,J. Michael White,Paul E. Swanson,Lloyd J. Old,Robert D. Schreiber +6 more
TL;DR: It is shown that lymphocytes and IFNγ collaborate to protect against development of carcinogen-induced sarcomas and spontaneous epithelial carcinomas and also to select for tumour cells with reduced immunogenicity, which explains the apparent paradox of tumour formation in immunologically intact individuals.
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The three Es of cancer immunoediting.
TL;DR: The history of the cancer immunosurveillance controversy is summarized and its resolution and evolution into the three Es of cancer immunoediting--elimination, equilibrium, and escape are discussed.