M. Saeed Khan

TL;DR: The signals generated by the steroid-SHBG-R(SHBG) complex generate messages that have effects on the transcriptional activity of classic, intracellular receptors for steroid hormones.

TL;DR: The binding of human sex hormone-binding globulin to a human prostatic cancer cell line (LNCaP) and the results of that binding were examined and demonstrate an additional mode of action of steroid hormones, one that does not require that the steroid interact with a steroid receptor.

TL;DR: It is established that binding to specific binding sites for Corticosteroid-Binding globulin results in the induction of adenylate cyclase activity and the accumulation of cAMP in MCF-7 cells, critically dependent upon a steroid being bound to CBG.

TL;DR: Specific binding sites for corticosteroid-binding globulin (CBG) were detected on membranes prepared from rat spleen, and electrophoretic patterns from uterine, pulmonary, and renal membranes showed that the less mobile band of the normal CBG doublet appeared to be metabolized to a greater extent than the more mobile band.

TL;DR: Cross-competition studies using the three 125I-labeled ligands and allowing each to compete with the three radioinert ligands indicated the existence of two separate receptors, which does not support a role for the CBG-receptor system in the entry of steroids into cells.