Maj-Lis Smith

TL;DR: By the use of intubation, muscle paralysis with suxamethonium chloride, and insertion of tail arterial and venous catheters, it was possible to induce reversible ischemia for long‐term recovery studies.

TL;DR: In situ hybridization was used to study expression of mRNAs for members of the nerve growth factor (NGF) family in the rat brain after 2 and 10 min of forebrain ischemia and 1 and 30 min of insulin-induced hypoglycemic coma to influence functional outcome and neuronal necrosis following ischemic and hypogly diabetic insults.

TL;DR: The results confirm previous findings showing that a decrease in temperature of only 2°C significantly reduces damage to several selectively vulnerable neuronal populations, and show that an increase in temperature significantly enhances brain damage.

TL;DR: The results suggest that whatever biochemical events are responsible for selective neuronal vulnerability, they are temperature sensitive; however, since there are differences in sensitivity between different parts of the brain, more than one mechanism may be involved.

TL;DR: It is shown that seizures induced by hippocampal kindling lead to a rapid, transient increase of trkB mRNA and protein in the hippocampus, suggesting that BDNF and its receptor may play a local role within the hippocampus in kindling-associated neural plasticity and in neuronal protection following epileptic, ischemic, and hypoglycemic insults.