M
Makoto Osanai
Researcher at Tohoku University
Publications - 56
Citations - 1663
Makoto Osanai is an academic researcher from Tohoku University. The author has contributed to research in topics: Calcium imaging & Ionotropic effect. The author has an hindex of 18, co-authored 54 publications receiving 1478 citations. Previous affiliations of Makoto Osanai include Nagoya University & Tokyo Medical and Dental University.
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Journal ArticleDOI
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.
Hiroki Fujita,Kotaro Sugimoto,Shuichiro Inatomi,Toshihiro Maeda,Makoto Osanai,Yasushi Uchiyama,Yoko Yamamoto,Takuro Wada,Takashi Kojima,Hiroshi Yokozaki,Toshihiko Yamashita,Shigeaki Kato,Norimasa Sawada,Hideki Chiba +13 more
TL;DR: It is shown, by using RNA interference and overexpression strategies, that claud in-2 and claudin-12 contribute to Ca(2+) absorption in intestinal epithelial cells, and a novel mechanism behind vitamin D-dependent calcium homeostasis is highlighted.
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Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel
Hironao Saegusa,Takashi Kurihara,Shuqin Zong,Osamu Minowa,An A. Kazuno,Wenhua Han,Yoshihiro Matsuda,Hitomi Yamanaka,Makoto Osanai,Tetsuo Noda,Tsutomu Tanabe +10 more
TL;DR: The results suggest that the α1E Ca2 + channel controls pain behaviors by both spinal and supraspinal mechanisms.
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Spinocerebellar Ataxia Type 6 Mutation Alters P-type Calcium Channel Function
Shuta Toru,Takayuki Murakoshi,Kinya Ishikawa,Hironao Saegusa,Hiroto Fujigasaki,Toshiki Uchihara,Shin Nagayama,Makoto Osanai,Hidehiro Mizusawa,Tsutomu Tanabe +9 more
TL;DR: Altered function of α1A(−NP) may contribute to degeneration of Purkinje cells, which express predominantly α1a(− NP), due to the reduced Ca2+ influx resulting from the negative shift of voltage-dependent inactivation.
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Orchestrated ensemble activities constitute a hippocampal memory engram.
Khaled Ghandour,Noriaki Ohkawa,Chi Chung Alan Fung,Hirotaka Asai,Yoshito Saitoh,Takashi Takekawa,Reiko Okubo-Suzuki,Shingo Soya,Hirofumi Nishizono,Mina Matsuo,Makoto Osanai,Masaaki Sato,Masamichi Ohkura,Masamichi Ohkura,Junichi Nakai,Yasunori Hayashi,Yasunori Hayashi,Takeshi Sakurai,Takashi Kitamura,Tomoki Fukai,Kaoru Inokuchi +20 more
TL;DR: The authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory.
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A Ca2+-induced Ca2+ release mechanism involved in asynchronous exocytosis at frog motor nerve terminals.
TL;DR: Ryanodine receptors in frog motor nerve terminals are endowed with Ca2- entry-dependent slow priming and fast inactivation mechanisms, as well as Ca2+ entry- dependent activation, and involved in asynchronous exocytosis.