Mariachiara Ippolito

TL;DR: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19.

TL;DR: A better understanding of SARS-CoV-2 transmission is needed, together with high-quality clinical data on the use of respirators or alternative devices, and healthcare workers, regardless of their level of experience, should receive specific training.

TL;DR: There is insufficient evidence regarding the clinical efficacy and safety of tocilizumab in patients with COVID-19 and its use should be considered experimental, requiring ethical approval and clinical trial oversight.

TL;DR: In this article, the authors provide an overview of available data about respiratory mechanics, gas exchange and mechanical ventilation settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps.

TL;DR: Treatment of hospitalized COVID-19 with CQ/HCQ may not reduce risk of death, compared to standard care and high dose regimens or combination with macrolides may be associated with harm.