M
Marius Schmidt
Researcher at University of Wisconsin–Milwaukee
Publications - 103
Citations - 4612
Marius Schmidt is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Femtosecond & Chromophore. The author has an hindex of 33, co-authored 96 publications receiving 3808 citations. Previous affiliations of Marius Schmidt include University of Mainz & European Synchrotron Radiation Facility.
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Journal ArticleDOI
Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein
Jason Tenboer,Shibom Basu,Nadia A. Zatsepin,Kanupriya Pande,Despina Milathianaki,Matthias Frank,Mark S. Hunter,Sébastien Boutet,Garth J. Williams,Jason E. Koglin,Dominik Oberthuer,Michael Heymann,Christopher Kupitz,Chelsie E. Conrad,Jesse Coe,Shatabdi Roy-Chowdhury,Uwe Weierstall,Daniel James,Dingjie Wang,Thomas D. Grant,Anton Barty,Oleksandr Yefanov,Jennifer Scales,Cornelius Gati,Carolin Seuring,Vukica Šrajer,Robert Henning,Peter Schwander,Raimund Fromme,Abbas Ourmazd,Keith Moffat,Jasper J. van Thor,John C. H. Spence,Petra Fromme,Henry N. Chapman,Marius Schmidt +35 more
TL;DR: This work used microcrystals of photoactive yellow protein as a model system and obtained high-resolution, time-resolved difference electron density maps of excellent quality with strong features, which open the way to the study of reversible and nonreversible biological reactions on time scales as short as femtoseconds under conditions that maximize the extent of reaction initiation throughout the crystal.
Journal ArticleDOI
Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein.
Kanupriya Pande,C. Hutchison,Gerrit Groenhof,Andrew Aquila,Josef S. Robinson,Jason Tenboer,Shibom Basu,Sébastien Boutet,Daniel P. DePonte,Mengning Liang,Thomas A. White,Nadia A. Zatsepin,Oleksandr Yefanov,Dmitry Morozov,Dominik Oberthuer,Cornelius Gati,Ganesh Subramanian,Daniel James,Yun Zhao,Jake Koralek,Jennifer Brayshaw,Christopher Kupitz,Chelsie E. Conrad,Shatabdi Roy-Chowdhury,Jesse Coe,Markus Metz,Paulraj Lourdu Xavier,Thomas D. Grant,Jason E. Koglin,Gihan K. Ketawala,Raimund Fromme,Vukica Šrajer,Robert Henning,John C. H. Spence,Abbas Ourmazd,Peter Schwander,Uwe Weierstall,Matthias Frank,Petra Fromme,Anton Barty,Henry N. Chapman,Keith Moffat,Jasper J. van Thor,Marius Schmidt +43 more
TL;DR: Structural changes associated with the earliest steps in the trans-to-cis isomerization of the chromophore in photoactive yellow protein are identified.
Journal ArticleDOI
Protein Conformational Relaxation and Ligand Migration in Myoglobin: A Nanosecond to Millisecond Molecular Movie from Time-Resolved Laue X-ray Diffraction†
Srajer,Z. Ren,T.-Y. Teng,Marius Schmidt,T. Ursby,Dominique Bourgeois,Claude Pradervand,Schildkamp W,Michael Wulff,Keith Moffat +9 more
TL;DR: These results demonstrate that structural changes as small as 0.2 A and populations of CO docking sites of 10% can be detected by time-resolved X-ray diffraction.
Journal ArticleDOI
Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds.
Hyotcherl Ihee,Sudarshan Rajagopal,Vukica Šrajer,R. Pahl,S. Anderson,Marius Schmidt,Friedrich Schotte,Philip A. Anfinrud,Michael Wulff,Keith Moffat +9 more
TL;DR: Time-resolved Laue crystallography is used to extract short-lived intermediate structures and thereby unveil signal transduction in the blue light photoreceptor photoactive yellow protein (PYP) from Halorhodospira halophila.
Journal ArticleDOI
Volume-conserving trans-cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography
Yang Ouk Jung,Jae Hyuk Lee,Joonghan Kim,Marius Schmidt,Keith Moffat,Vukica Šrajer,Hyotcherl Ihee +6 more
TL;DR: Time-resolved X-ray crystallography is employed to structurally visualize isomerization of the p-coumaric acid chromophore in photoactive yellow protein with 100 picosecond time resolution and 1.6 Å spatial resolution.