M
Mark J.D. Griffiths
Researcher at National Institutes of Health
Publications - 114
Citations - 5881
Mark J.D. Griffiths is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Lung injury & ARDS. The author has an hindex of 33, co-authored 112 publications receiving 4966 citations. Previous affiliations of Mark J.D. Griffiths include Harefield Hospital & Imperial College London.
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Journal ArticleDOI
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)
Moronke A. Noah,Giles J. Peek,Simon J. Finney,Mark J.D. Griffiths,David A Harrison,Richard Grieve,M Zia Sadique,Jasjeet S. Sekhon,Daniel F. McAuley,Richard K. Firmin,Chris Harvey,Jeremy J. Cordingley,Susanna Price,Alain Vuylsteke,David P. Jenkins,David W Noble,Roxanna Bloomfield,Timothy S. Walsh,Gavin D. Perkins,David K. Menon,Bruce L. Taylor,Kathryn M Rowan +21 more
TL;DR: For patients with H1N1-related ARDS, referral and transfer to an ECMO center was associated with lower hospital mortality compared with matched non-ECMO-referred patients, and the results were robust to sensitivity analyses.
Journal ArticleDOI
TGF-β is a critical mediator of acute lung injury
Jean-Francois Pittet,Mark J.D. Griffiths,Tom Geiser,Naftali Kaminski,Stephen L. Dalton,Xiaozhu Huang,Lou Anne S. Brown,Phillip J. Gotwals,Victor Koteliansky,Michael A. Matthay,Dean Sheppard +10 more
TL;DR: It is shown that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI), and that blocking TGF-beta or its activation could be effective treatments for this currently untreatable disorder.
Journal ArticleDOI
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis
Naftali Kaminski,John Allard,Jean F. Pittet,Fengrong Zuo,Mark J.D. Griffiths,David R. Morris,Xiaozhu Huang,Dean Sheppard,Renu A. Heller +8 more
TL;DR: Analysis of gene expression at multiple time points after bleomycin administration revealed sequential induction of subsets of genes that characterize each response in pulmonary fibrosis.
Journal ArticleDOI
Ventilator-associated lung injury
TL;DR: The effects of mechanical ventilation on injured lungs and the underlying mechanisms are outlined and modified so that VALI is kept to a minimum improves survival of patients with ARDS.
Journal ArticleDOI
Inhaled Nitric Oxide Therapy in Adults
TL;DR: The therapeutic promise of nitric oxide (NO), a potent vasodilator, remains uncertain for adults, and licensed indications are restricted to pediatric practice.