M
Mauro D'Amato
Researcher at Ikerbasque
Publications - 195
Citations - 20935
Mauro D'Amato is an academic researcher from Ikerbasque. The author has contributed to research in topics: Inflammatory bowel disease & Population. The author has an hindex of 49, co-authored 179 publications receiving 17009 citations. Previous affiliations of Mauro D'Amato include University of Kiel & Sapienza University of Rome.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Andre Franke,Dermot P.B. McGovern,Jeffrey C. Barrett,Kai Wang,Graham L. Radford-Smith,Tariq Ahmad,Charlie W. Lees,Tobias Balschun,James Lee,Rebecca L. Roberts,Carl A. Anderson,Joshua C. Bis,Suzanne Bumpstead,David Ellinghaus,Eleonora M. Festen,Michel Georges,Todd Green,Talin Haritunians,Luke Jostins,Anna Latiano,Christopher G. Mathew,Grant W. Montgomery,Natalie J. Prescott,Soumya Raychaudhuri,Jerome I. Rotter,Philip Schumm,Yashoda Sharma,Lisa A. Simms,Kent D. Taylor,David C. Whiteman,Cisca Wijmenga,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Albert Cohen,Jean Frederick Colombel,Mario Cottone,Laura Stronati,Ted Denson,Martine De Vos,Renata D'Incà,Marla Dubinsky,Cathryn Edwards,Timothy H. Florin,Denis Franchimont,Richard B. Gearry,Jürgen Glas,Jürgen Glas,Jürgen Glas,André Van Gossum,Stephen L. Guthery,Jonas Halfvarson,Hein W. Verspaget,Jean-Pierre Hugot,Amir Karban,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Craig Mowat,William G. Newman,Julián Panés,Anne M. Phillips,Deborah D. Proctor,Miguel Regueiro,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Frank Seibold,A. Hillary Steinhart,Pieter C. F. Stokkers,Leif Törkvist,Gerd A. Kullak-Ublick,David C. Wilson,Thomas D. Walters,Stephan R. Targan,Steven R. Brant,John D. Rioux,Mauro D'Amato,Rinse K. Weersma,Subra Kugathasan,Anne M. Griffiths,John C. Mansfield,Severine Vermeire,Richard H. Duerr,Mark S. Silverberg,Jack Satsangi,Stefan Schreiber,Judy H. Cho,Vito Annese,Hakon Hakonarson,Mark J. Daly,Miles Parkes +97 more
TL;DR: A meta-analysis of six Crohn's disease genome-wide association studies and a series of in silico analyses highlighted particular genes within these loci implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP.
Journal ArticleDOI
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
David Ellinghaus,Frauke Degenhardt,Luis Bujanda,Maria Buti,Agustín Albillos,Pietro Invernizzi,J. Fernández,Daniele Prati,Guido Baselli,Rosanna Asselta,Marit Mæhle Grimsrud,Chiara Milani,Fatima Aziz,Jan Christian Kässens,Sandra May,Mareike Wendorff,Lars Wienbrandt,Florian Uellendahl-Werth,Tenghao Zheng,Xiaoli Yi,Raúl de Pablo,Adolfo Garrido Chercoles,Adriana Palom,Alba Estela Garcia-Fernandez,Francisco Rodriguez-Frias,Alberto Zanella,Alessandra Bandera,Alessandro Protti,Alessio Aghemo,Ana Lleo,Andrea Biondi,Andrea Caballero-Garralda,Andrea Gori,Anja Tanck,Anna Carreras Nolla,Anna Latiano,Anna Ludovica Fracanzani,Anna Peschuck,Antonio Julià,Antonio Pesenti,Antonio Voza,David Jiménez,Beatriz Mateos,Beatriz Nafria Jimenez,Carmen Quereda,Cinzia Paccapelo,Christoph Gassner,Claudio Angelini,Cristina Cea,Aurora Solier,David Pestana,Eduardo Muñiz-Diaz,Elena Sandoval,Elvezia Maria Paraboschi,Enrique Navas,Félix García Sánchez,Ferruccio Ceriotti,F. Martinelli-Boneschi,Flora Peyvandi,Francesco Blasi,Luis Téllez,Albert Blanco-Grau,Georg Hemmrich-Stanisak,Giacomo Grasselli,Giorgio Costantino,Giulia Cardamone,Giuseppe Foti,Serena Aneli,Hayato Kurihara,Hesham ElAbd,Ilaria My,Iván Galván-Femenía,Javier Martin,Jeanette Erdmann,José Ferrusquía-Acosta,Koldo Garcia-Etxebarria,Laura Izquierdo-Sanchez,Laura Rachele Bettini,Lauro Sumoy,Leonardo Terranova,Leticia Moreira,Luigi Santoro,Luigia Scudeller,Francisco Mesonero,Luisa Roade,Malte C. Rühlemann,Marco Schaefer,Maria Carrabba,Mar Riveiro-Barciela,Maria Eloina Figuera Basso,Maria Grazia Valsecchi,María Hernández-Tejero,Marialbert Acosta-Herrera,Mariella D'Angiò,Marina Baldini,Marina Cazzaniga,Martin Schulzky,Maurizio Cecconi,Michael Wittig,Michele Ciccarelli,Miguel Rodríguez-Gandía,Monica Bocciolone,Monica Miozzo,Nicola Montano,Nicole Braun,Nicoletta Sacchi,Nilda Martinez,Onur Özer,Orazio Palmieri,Paola Faverio,Paoletta Preatoni,Paolo Bonfanti,Paolo Omodei,Paolo Tentorio,Pedro Castro,Pedro M. Rodrigues,Aaron Blandino Ortiz,Rafael de Cid,Ricard Ferrer,Roberta Gualtierotti,Rosa Nieto,Siegfried Goerg,Salvatore Badalamenti,Sara Marsal,Giuseppe Matullo,Serena Pelusi,Simonas Juzenas,Stefano Aliberti,Valter Monzani,Victor Moreno,Tanja Wesse,Tobias L. Lenz,Tomás Pumarola,Valeria Rimoldi,Silvano Bosari,Wolfgang Albrecht,Wolfgang Peter,Manuel Romero-Gómez,Mauro D'Amato,Stefano Duga,Jesus M. Banales,Johannes R. Hov,Trine Folseraas,Luca Valenti,Andre Franke,Tom H. Karlsen +145 more
TL;DR: A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed.
Journal ArticleDOI
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Carl A. Anderson,Gabrielle Boucher,Charlie W. Lees,Andre Franke,Mauro D'Amato,Kent D. Taylor,James Lee,Philippe Goyette,Marcin Imielinski,Anna Latiano,Caroline Lagacé,Regan Scott,Leila Amininejad,Suzannah Bumpstead,Leonard Baidoo,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Jean-Frederic Colombel,Lee A. Denson,Martine De Vos,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Rudolf S N Fehrmann,James A B Floyd,Timothy H. Florin,Denis Franchimont,Lude Franke,Michel Georges,Jürgen Glas,Nicole L. Glazer,Stephen L. Guthery,Talin Haritunians,Nicholas K. Hayward,Jean-Pierre Hugot,Gilles Jobin,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Dermot P.B. McGovern,Monica Milla,Grant W. Montgomery,Katherine I. Morley,Craig Mowat,Aylwin Ng,William G. Newman,Roel A. Ophoff,Laura Papi,Orazio Palmieri,Laurent Peyrin-Biroulet,Julián Panés,Anne M. Phillips,Natalie J. Prescott,Deborah D. Proctor,Rebecca L. Roberts,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Philip Schumm,Frank Seibold,Yashoda Sharma,Lisa A. Simms,Mark Seielstad,Mark Seielstad,A. Hillary Steinhart,Stephan R. Targan,Leonard H. van den Berg,Morten H. Vatn,Hein W. Verspaget,Thomas D. Walters,Cisca Wijmenga,David C. Wilson,Harm-Jan Westra,Ramnik J. Xavier,Zhen Zhen Zhao,Cyriel Y. Ponsioen,Vibeke Andersen,Leif Törkvist,Maria Gazouli,Nicholas P. Anagnou,Tom H. Karlsen,Limas Kupčinskas,Jurgita Sventoraityte,John C. Mansfield,Subra Kugathasan,Mark S. Silverberg,Jonas Halfvarson,Jerome I. Rotter,Christopher G. Mathew,Anne M. Griffiths,Richard B. Gearry,Tariq Ahmad,Steven R. Brant,Mathias Chamaillard,Jack Satsangi,Judy H. Cho,Stefan Schreiber,Mark J. Daly,Jeffrey C. Barrett,Miles Parkes,Vito Annese,Hakon Hakonarson,Graham L. Radford-Smith,Richard H. Duerr,Severine Vermeire,Rinse K. Weersma,John D. Rioux +113 more
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Journal ArticleDOI
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Manuel A. Rivas,Manuel A. Rivas,Manuel A. Rivas,Mélissa Beaudoin,Agnes Gardet,Christine Stevens,Yashoda Sharma,Clarence K. Zhang,Gabrielle Boucher,Stephan Ripke,Stephan Ripke,David Ellinghaus,Noël P. Burtt,Timothy Fennell,Andrew Kirby,Andrew Kirby,Anna Latiano,Philippe Goyette,Todd Green,Jonas Halfvarson,Talin Haritunians,Joshua M. Korn,Finny G Kuruvilla,Caroline Lagacé,Benjamin M. Neale,Benjamin M. Neale,Ken Sin Lo,Phil Schumm,Leif Törkvist,Marla Dubinsky,Steven R. Brant,Mark S. Silverberg,Richard H. Duerr,David Altshuler,David Altshuler,Stacey Gabriel,Guillaume Lettre,Andre Franke,Mauro D'Amato,Dermot P.B. McGovern,Judy H. Cho,John D. Rioux,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,Mark J. Daly +45 more
TL;DR: Next-generation sequencing is used to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls to identify new, rare and probably functional variants that could aid functional experiments and predictive models.