M
Mengjia Song
Researcher at Sun Yat-sen University
Publications - 12
Citations - 634
Mengjia Song is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Tumor microenvironment & Medicine. The author has an hindex of 6, co-authored 9 publications receiving 142 citations. Previous affiliations of Mengjia Song include Zhengzhou University.
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Journal ArticleDOI
Roles of IFN-γ in tumor progression and regression: a review.
TL;DR: The current knowledge concerning the roles of IFN-γ in the TME as a part of the complex immune response to cancer is discussed and the importance of identifying IFn-γ responsive patients to improve their sensitivity to immuno-therapies is highlighted.
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Cancer‐Associated Fibroblast‐Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression
Mengjia Song,Junyi He,Qiu-Zhong Pan,J. Yang,Jing Jing Zhao,Yaojun Zhang,Yue Huang,Yan Tang,Qijing Wang,Jia He,Jia-Mei Gu,Yongqiang Li,Shi-Ping Chen,Jianxiong Zeng,Zi-Qi Zhou,Chaopin Yang,Yulong Han,Hao Chen,Tong Xiang,De-Sheng Weng,Jian-Chuan Xia +20 more
TL;DR: In this paper, the authors investigated the cellular crosstalk among CAFs, tumor cells, and tumor-associated neutrophils (TANs) during different stages of HCC pathogenesis.
Journal ArticleDOI
Low-Dose IFNγ Induces Tumor Cell Stemness in Tumor Microenvironment of Non–Small Cell Lung Cancer
Mengjia Song,Mengjia Song,Yu Ping,Kai Zhang,Li Yang,Feng Li,Chaoqi Zhang,Chaoqi Zhang,Shaoyan Cheng,Dongli Yue,Nomathamsanqa Resegofetse Maimela,Jiao Qu,Shasha Liu,Ting Sun,Zihai Li,Jianchuan Xia,Bin Zhang,Liping Wang,Yi Zhang +18 more
TL;DR: In this paper, the authors reveal a dose-dependent effect of IFNγ in inducing tumor stemness to accelerate cancer progression in patients with a variety of cancer types, and elucidate the distinct molecular mechanisms activated by the inflammatory cytokine in a dosedependent manner.
Journal ArticleDOI
PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy
Siwei Tan,Xuxia Wei,Mengjia Song,Jin Tao,Yunpeng Yang,S Khatoon,Huanliang Liu,Ji-Jun Jiang,Benquan Wu +8 more
TL;DR: Results indicate that PUMA mediates ER stress-induced mucosal epithelial apoptosis through the mitochondrial apoptotic pathway in PHG, and thatPUMA is a potentially therapeutic target for PHG.
Journal ArticleDOI
Galectin-3 favours tumour metastasis via the activation of β-catenin signalling in hepatocellular carcinoma.
Mengjia Song,Qiu-Zhong Pan,J. Yang,Junyi He,Jianxiong Zeng,Shaoyan Cheng,Yue Huang,Zi-Qi Zhou,Qian Zhu,Chaopin Yang,Yulong Han,Yan Tang,Hao Chen,De-Sheng Weng,Jian-Chuan Xia +14 more
TL;DR: The Galectin-3-β-catenin-IGFBP3/vimentin signalling cascade was determined as a central mechanism controlling HCC metastasis, providing possible biomarkers for predicating vascular metastasis and sorafenib resistance, as well as potential therapeutic targets for the treatment of HCC patients.