M
Michael A. Hill
Researcher at University of Missouri
Publications - 196
Citations - 10100
Michael A. Hill is an academic researcher from University of Missouri. The author has contributed to research in topics: Vascular smooth muscle & Cremaster muscle. The author has an hindex of 52, co-authored 183 publications receiving 8461 citations. Previous affiliations of Michael A. Hill include University of Virginia & Eastern Virginia Medical School.
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Journal ArticleDOI
Signaling mechanisms underlying the vascular myogenic response
Michael J. Davis,Michael A. Hill +1 more
TL;DR: The purpose of this review is to summarize and synthesize information regarding the cellular mechanism(s) underlying the myogenic response in blood vessels, with particular emphasis on arterioles.
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Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity.
TL;DR: A contemporary view is provided of the instigators of diabetic cardiomyopathy, as well as mechanistically based strategies for the prevention and treatment of diabetic CARDIomyopathy.
Journal ArticleDOI
Invited Review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity
TL;DR: The smooth muscle of arterioles responds to an increase in intraluminal pressure with vasoconstriction and with vasodilation when pressure is decreased, and the purpose of this brief review is to summarize the current literature relating to Ca(2+) and the arteriolar myogenic response.
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Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
Amy McCurley,Paulo W. Pires,Shawn B. Bender,Mark Aronovitz,Michelle J Zhao,Daniel Metzger,Pierre Chambon,Michael A. Hill,Anne M. Dorrance,Michael E Mendelsohn,Michael E Mendelsohn,Iris Z. Jaffe +11 more
TL;DR: It is shown that mice with SMC-specific deficiency of the MR have decreased blood pressure as they age without defects in renal sodium handling or vascular structure, which supports the emerging hypothesis that vascular tone contributes directly to systemic blood pressure.
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The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure.
TL;DR: It is hypothesized that the existence of a remodeling continuum that allows for the vascular wall to rapidly modify its structural characteristics, specifically through the re-positioning of vascular smooth muscle cells, provides resistance vessels the ability to maintain a desired diameter under presumed optimal energetic and mechanical conditions.