M
Michael D. Shapiro
Researcher at Wake Forest University
Publications - 291
Citations - 11614
Michael D. Shapiro is an academic researcher from Wake Forest University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 44, co-authored 228 publications receiving 9496 citations. Previous affiliations of Michael D. Shapiro include Oregon Health & Science University & University of Utah.
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Journal ArticleDOI
Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer
Yingguang Frank Chan,Melissa E. Marks,Felicity C. Jones,Guadalupe Villarreal,Michael D. Shapiro,Shannon D. Brady,Audrey Southwick,Devin Absher,Jane Grimwood,Jeremy Schmutz,Richard M. Myers,Dmitri A. Petrov,Bjarni Jónsson,Dolph Schluter,Michael A. Bell,David M. Kingsley +15 more
TL;DR: These studies illustrate how major expression and morphological changes can arise from single mutational leaps in natural populations, producing new adaptive alleles via recurrent regulatory alterations in a key developmental control gene.
Journal ArticleDOI
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks
Michael D. Shapiro,Melissa E. Marks,Catherine L. Peichel,Benjamin K. Blackman,Kirsten S. Nereng,Bjarni Jónsson,Dolph Schluter,David M. Kingsley +7 more
TL;DR: Regulatory mutations in major developmental control genes may provide a mechanism for generating rapid skeletal changes in natural populations, while preserving the essential roles of these genes in other processes.
Journal ArticleDOI
Diagnostic and Prognostic Value of Absence of Coronary Artery Calcification
Ammar Sarwar,Leslee J. Shaw,Michael D. Shapiro,Ron Blankstein,Udo Hoffman,Ricardo C. Cury,Suhny Abbara,Thomas J. Brady,Matthew J. Budoff,Roger S. Blumenthal,Khurram Nasir,Khurram Nasir,Khurram Nasir +12 more
TL;DR: It is concluded that the absence of CAC is associated with a very low risk of future cardiovascular events, with modest incremental value of other diagnostic tests in this very low-risk group.
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Coronary Computed Tomography Angiography for Early Triage of Patients With Acute Chest Pain: The ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) Trial
Udo Hoffmann,Fabian Bamberg,Claudia U. Chae,John H. Nichols,Ian S. Rogers,Sujith K. Seneviratne,Quynh A. Truong,Ricardo C. Cury,Suhny Abbara,Michael D. Shapiro,Jamaluddin Moloo,Javed Butler,Maros Ferencik,Hang Lee,Ik-Kyung Jang,Blair A. Parry,David F.M. Brown,James E. Udelson,Stephan Achenbach,Thomas J. Brady,John T. Nagurney +20 more
TL;DR: Fifty percent of patients with acute chest pain and low to intermediate likelihood of ACS were free of CAD by computed tomography and had no ACS, suggesting early coronary CTA may significantly improve patient management in the emergency department.
Journal ArticleDOI
Dual-Energy X-Ray Absorptiometry for Quantification of Visceral Fat
Sanjiv Kaul,Megan P. Rothney,Dawn Peters,Wynn K. Wacker,Cynthia Elizabeth Landberg Davis,Michael D. Shapiro,David L. Ergun +6 more
TL;DR: DXA can measure abdominal VF precisely in both men and women and this simple noninvasive method with virtually no radiation can therefore be used to measure VF in individual patients and help define diabetes and cardiovascular risk.