Michael J. O'Connor

TL;DR: Examination of human adult tau from brain biopsies demonstrated that biopsy-derived tau is phosphorylated at most sites thought to be abnormally phosphorylate tau, suggesting that the down-regulation of phosphatases in the AD brain could lead to the generation of maximallyosphorylated PHF-tau that does not bind microtubules and aggregates as PHFs in neurofibrillary tangles and dystrophic neurites.

TL;DR: Elimination of seizures after surgery reduces mortality rates in people with epilepsy to a level indistinguishable from that of the general population, whereas patients with recurrent seizures continue to suffer from high mortality rates, suggesting that uncontrolled seizures are a major risk factor for excess mortality in epilepsy.

TL;DR: Temporal lobectomy provides sustained seizure relief over 5 years to most patients who have surgery, and a seizure-free state is associated with reduced mortality and increased employment.

TL;DR: The study of the expression of CXCR-4 in the brain may provide further insight into the interactions between brain cells, pathogens, and the immune system, and help understand the pathogenesis of HIV dementia.

TL;DR: The overall prevalence of psychiatric dysfunction was comparably high before and after ATL, but individual changes in psychiatric status and changes in severity of symptoms occurred in many patients in the 6 months after surgery.