M
Mikael J. Pittet
Researcher at Harvard University
Publications - 188
Citations - 36922
Mikael J. Pittet is an academic researcher from Harvard University. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 77, co-authored 172 publications receiving 29588 citations. Previous affiliations of Mikael J. Pittet include University of Geneva & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more
TL;DR: By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
Journal ArticleDOI
Imaging in the era of molecular oncology
TL;DR: Advances in experimental and clinical imaging are likely to improve how cancer is understood at a systems level and should enable doctors not only to locate tumours but also to assess the activity of the biological processes within these tumours and to provide 'on the spot' treatment.
Journal ArticleDOI
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Filip K. Swirski,Matthias Nahrendorf,Martin Etzrodt,Martin Etzrodt,Moritz Wildgruber,Virna Cortez-Retamozo,Peter Panizzi,Jose-Luiz Figueiredo,Rainer H. Kohler,Aleksey Chudnovskiy,Peter Waterman,Elena Aikawa,Thorsten R. Mempel,Peter Libby,Ralph Weissleder,Mikael J. Pittet +15 more
TL;DR: It is shown that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation and identifies splenic monocytes as a resource that the body exploits to regulate inflammation.
Journal ArticleDOI
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Matthias Nahrendorf,Filip K. Swirski,Elena Aikawa,Lars Stangenberg,Thomas Wurdinger,Jose-Luiz Figueiredo,Peter Libby,Peter Libby,Ralph Weissleder,Mikael J. Pittet +9 more
TL;DR: This work identifies two distinct phases of monocyte participation after MI and proposes a model that reconciles the divergent properties of these cells in healing and identifies new therapeutic targets that can influence healing and ventricular remodeling after MI.
Journal ArticleDOI
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Sophie Viaud,Sophie Viaud,Fabiana Saccheri,Grégoire Mignot,Takahiro Yamazaki,Romain Daillère,Romain Daillère,Dalil Hannani,David Enot,David Enot,Christina Pfirschke,Camilla Engblom,Mikael J. Pittet,Andreas Schlitzer,Florent Ginhoux,Lionel Apetoh,Elisabeth Chachaty,Paul Louis Woerther,Gérard Eberl,Marion Bérard,Chantal Ecobichon,Chantal Ecobichon,Dominique Clermont,Chantal Bizet,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau,Nadine Cerf-Bensussan,Nadine Cerf-Bensussan,Paule Opolon,Nadia Yessaad,Eric Vivier,Bernhard Ryffel,Charles O. Elson,Joël Doré,Joël Doré,Guido Kroemer,Patricia Lepage,Patricia Lepage,Ivo G. Boneca,Ivo G. Boneca,François Ghiringhelli,François Ghiringhelli,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel +44 more
TL;DR: It is demonstrated that cyclophosphamide alters the composition of microbiota in the small intestine and induces the translocation of selected species of Gram-positive bacteria into secondary lymphoid organs, which suggests that the gut microbiota help shape the anticancer immune response.