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Naoko Hata-Sugi
Researcher at Eisai
Publications - 4
Citations - 407
Naoko Hata-Sugi is an academic researcher from Eisai. The author has contributed to research in topics: Angiogenesis inhibitor & Schizosaccharomyces pombe. The author has an hindex of 4, co-authored 4 publications receiving 315 citations.
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Journal ArticleDOI
Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models
Osamu Tohyama,Junji Matsui,Kotaro Kodama,Naoko Hata-Sugi,Takayuki Kimura,Kiyoshi Okamoto,Yukinori Minoshima,Masao Iwata,Yasuhiro Funahashi +8 more
TL;DR: Data demonstrate that lenvatinib provides antitumor activity mainly via angiogenesis inhibition but also inhibits FGFR and RET signaling pathway in preclinical human thyroid cancer models.
Journal ArticleDOI
Schizosaccharomyces pombe och1 + encodes α‐1,6‐mannosyltransferase that is involved in outer chain elongation of N‐linked oligosaccharides
Takehiko Yoko-o,Kappei Tsukahara,Tatsuo Watanabe,Naoko Hata-Sugi,Kentaro Yoshimatsu,Takeshi Nagasu,Yoshifumi Jigami +6 more
TL;DR: The results indicate that SpOch1p is a key enzyme of outer chain elongation, and the substrate specificity of SpOCh1p was different from that of S. cerevisiae OCH1 gene product (ScOch2p), suggesting that Sp och1P may have a wider substrate specificity than that of ScOch 1p.
Journal ArticleDOI
Characterization of rat aortic fragment within collagen gel as an angiogenesis model; capillary morphology may reflect the action mechanisms of angiogenesis inhibitors.
TL;DR: The results suggest that the capillary structure in this rat aorta model is dramatically influenced by the inhibition of angiogenic signalling and extracellular matrix (ECM) degradation.
Journal ArticleDOI
Anticancer agent E7070 inhibits amino acid and uracil transport in fission yeast.
Kappei Tsukahara,Tatsuo Watanabe,Naoko Hata-Sugi,Kentaro Yoshimatsu,Hiroto Okayama,Takeshi Nagasu +5 more
TL;DR: It is shown that E7070 inhibits imports of amino acid and uracil into S. pombe cells, suggesting that some of the molecular targets for E 7070 action in S.pombe are likely to be leucine and urACil transporters.