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Navdeep S. Chandel
Researcher at Northwestern University
Publications - 328
Citations - 59666
Navdeep S. Chandel is an academic researcher from Northwestern University. The author has contributed to research in topics: Mitochondrion & Reactive oxygen species. The author has an hindex of 99, co-authored 286 publications receiving 46249 citations. Previous affiliations of Navdeep S. Chandel include University of Chicago & University of Illinois at Chicago.
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Journal ArticleDOI
ROS Promotes Cancer Cell Survival through Calcium Signaling
TL;DR: A novel, non-canonical oxidative stress defense mechanism involving TRPA1, a redox-sensitive Ca2+ channel, and the upregulation of anti-apoptotic pathways to promote cancer cell survival is identified.
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Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption *
Iliana Herrera,José Cisneros,Mariel Maldonado,Remedios Ramírez,Blanca Ortiz-Quintero,Elena Anso,Navdeep S. Chandel,Moisés Selman,Annie Pardo +8 more
TL;DR: The findings indicate that epithelial expression of MMP-1 inhibits mitochondrial function, increases HIF-1α expression, decreases reactive oxygen species production, and contributes to a proliferative, migratory, and anti-apoptotic AEC phenotype.
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Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species.
Eric L. Bell,Navdeep S. Chandel +1 more
TL;DR: The model in which mitochondria regulate the stability of HIF through the increased production of ROS (reactive oxygen species) during hypoxia is outlined.
Journal ArticleDOI
Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes.
G. R. S. Budinger,Navdeep S. Chandel,Zuo-Hui Shao,Chang Qing Li,A. Melmed,L. B. Becker,Paul T. Schumacker +6 more
TL;DR: It is demonstrated that embryonic chick cardiac myocytes can suppress their rates of ATP demand, ATP utilization, and O2 uptake during moderate hypoxia through a mechanism that involves a reversible inhibition of cytochrome-c oxidase.
Journal ArticleDOI
Death Induced by CD95 or CD95 Ligand Elimination
Abbas Hadji,Paolo Ceppi,Andrea E. Murmann,Sonia Brockway,Abhinandan Pattanayak,Bhavneet Bhinder,Annika Hau,Shirley De Chant,Vamsi Parimi,Piotre Kolesza,Jo Anne S. Richards,Navdeep S. Chandel,Hakim Djaballah,Marcus E. Peter +13 more
TL;DR: It is shown that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL expression, and preferentially affects cancer cells.