N
Nicholas R. Lemoine
Researcher at Queen Mary University of London
Publications - 321
Citations - 22095
Nicholas R. Lemoine is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 83, co-authored 314 publications receiving 20656 citations. Previous affiliations of Nicholas R. Lemoine include Imperial College London & University of Wales.
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Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS).
Ajay K. Kakkar,Mark Levine,Zbigniew Kadziola,Nicholas R. Lemoine,Vanessa Low,Heman K. Patel,Gordon J. S. Rustin,Michael Thomas,Mary Quigley,Robin C.N. Williamson +9 more
TL;DR: Dalteparin administration did not significantly improve 1-year survival rates in patients with advanced malignancy, however, the observed improved survival in a subgroup of patients with a better prognosis suggests a potential modifying effect of dALTeparin on tumor biology.
Journal ArticleDOI
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
L. Miguel Martins,Ingram Iaccarino,Tencho Tenev,Stephen Gschmeissner,Nicholas F. Totty,Nicholas R. Lemoine,John Savopoulos,Carol W. Gray,Caretha L. Creasy,Colin Dingwall,Julian Downward +10 more
TL;DR: The serine protease Omi/HtrA2 is identified as a second mammalian XIAP-binding protein with a Reaper-like motif, and this protease autoprocesses to form a protein with amino-terminal homology to Smac/DIABLO and Reaper family proteins.
Journal Article
High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.
Nicholas R. Lemoine,Mayall Es,F. S. Wyllie,Williams Ed,M Goyns,B Stringer,David Wynford-Thomas +6 more
TL;DR: Using polymerase chain reaction amplification and oligonucleotide probing, the activation of ras oncogenes in 24 benign and 20 malignant human thyroid neoplasms was examined, and while transition mutations predominated in differentiated tumours, transversions were more common in the undifferentiated tumours.
Journal ArticleDOI
The type 1 (EGFR-related) family of growth factor receptors and their ligands.
TL;DR: The involvement of these receptors and growth factors in human cancer has implications for the design of novel forms of therapy for cancer, and recent advances and future avenues for investigation are reviewed.
Journal ArticleDOI
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Patrick S. Moore,Bence Sipos,Simonetta Orlandini,Claudio Sorio,Francisco X. Real,Nicholas R. Lemoine,Thomas M. Gress,Claudio Bassi,G. Klöppel,Holger Kalthoff,Hendrik Ungefroren,Matthias Löhr,Aldo Scarpa +12 more
TL;DR: This comprehensive data regarding the cumulative genetic alterations in pancreatic carcinoma cell lines will be of great value for studies involving drug sensitivity or resistance that may be associated with inactivation of a particular gene or molecular pathway.