N
Nico van Rooijen
Researcher at VU University Amsterdam
Publications - 514
Citations - 69830
Nico van Rooijen is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 130, co-authored 513 publications receiving 62623 citations. Previous affiliations of Nico van Rooijen include Vanderbilt University Medical Center & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Journal ArticleDOI
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Ludovic Arnold,Adeline Henry,Françoise Poron,Yasmine Baba-Amer,Nico van Rooijen,Anne Plonquet,Romain K. Gherardi,Bénédicte Chazaud +7 more
TL;DR: In conclusion, injured skeletal muscle recruits monocyte (MO) exhibiting inflammatory profiles that operate phagocytosis and rapidly convert to antiinflammatory MPs that stimulate myogenesis and fiber growth.
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CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.
Ravindra Majeti,Mark P. Chao,Ash A. Alizadeh,Wendy W. Pang,Siddhartha Jaiswal,Kenneth D. Gibbs,Nico van Rooijen,Irving L. Weissman +7 more
TL;DR: It is found that increased CD47 expression is an independent, poor prognostic factor that can be targeted on human AML stem cells with blocking monoclonal antibodies capable of enabling phagocytosis of LSC.
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Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation
Stephen J. Jenkins,Dominik Rückerl,Peter C. Cook,Lucy H. Jones,Fred D. Finkelman,Fred D. Finkelman,Nico van Rooijen,Andrew S. MacDonald,Judith E. Allen +8 more
TL;DR: It is revealed that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density, and expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.
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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
Frank Tacke,David Alvarez,Theodore J. Kaplan,Claudia Jakubzick,Rainer Spanbroek,Jaime Llodra,Alexandre Garin,Jianhua Liu,Matthias Mack,Nico van Rooijen,Sergio A. Lira,Andreas J. R. Habenicht,Gwendalyn J. Randolph +12 more
TL;DR: Analyzing mouse monocyte subsets in apoE-deficient mice and tracing their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques suggests antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their C CR2-dependent responses to inflammation overall.