N
Nicole Schaeren-Wiemers
Researcher at University Hospital of Basel
Publications - 80
Citations - 5702
Nicole Schaeren-Wiemers is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Myelin & Oligodendrocyte. The author has an hindex of 36, co-authored 79 publications receiving 5165 citations. Previous affiliations of Nicole Schaeren-Wiemers include University of Zurich & ETH Zurich.
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A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes.
TL;DR: A simple non-radioactive in situ hybridization procedure for tissue sections and cultured cells using digoxigenin-labelled cRNA probes for the detection of various transcripts present at a wide range of expression levels in the central nervous system is developed.
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Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.
Michael Becker-André,Irmgard Wiesenberg,Nicole Schaeren-Wiemers,Elisabeth André,Martin Missbach,Jean-Hilaire Saurat,Carsten Carlberg +6 more
TL;DR: In this paper, the pineal gland hormone melatonin was identified as a ligand for the recently cloned orphan receptor retinoid Z receptor beta (RZR beta).
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Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth
Stefanie Rauskolb,Marta Zagrebelsky,Anita Dreznjak,Rubén Deogracias,Tomoya Matsumoto,Stefan Wiese,Beat Erne,Michael Sendtner,Nicole Schaeren-Wiemers,Martin Korte,Yves-Alain Barde +10 more
TL;DR: It is found that BDNF markedly promotes the growth of cultured striatal neurons and of their dendrites, but not of those of hippocampal neurons, suggesting that the differential responsiveness to BDNF is part of a neuron-intrinsic program.
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Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult.
TL;DR: The geneexpression pattern of 12 samples of normal appearing white matter from 10 post‐mortem MS brains is studied, introducing novel concepts of the molecular pathogenesis of MS with ischemic preconditioning as a major mechanism for neuroprotection.
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Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection
TL;DR: The data suggests an endogenous inflammatory reaction throughout the whole white matter of multiple sclerosis brain, in which oligodendrocytes actively participate, and this reaction might further influence and to some extent facilitate lesion formation.