Paolo Enrico

TL;DR: The data suggest that mesocortical dopamine neurons, at the level of the VTA, are tonicly excitated by glutamatergic neurons by acting on NMDA and non-NMDA receptors and are tonicsly inhibited by GABA and dopamine by actingon GABAA and D2 receptors.

TL;DR: The results indicate that a glutamatergic projection to the VTA, acting via both NMDA and non-NMDA-glutamate receptors, play a major role in the handling stress-induced increase in dopamine release in the mPFC and suggest a certain role for GABAergic neurones,acting via GABA(B) receptors, in thehandling response.

TL;DR: In‐vivo and in‐vitro evidence is provided for a key role of ACD in the motivational properties of EtOH and its activation of the mesolimbic DA system and suggest that ACD, by increasing VTA DA neuronal activity, would oppose its well‐known peripherally originating aversive properties.

TL;DR: The ability of 4-MP and DP to decrease EtOH-induced cpp suggests that a reduction of ACD levels is crucial in depriving EtOH from its motivational properties as indexed by the cpp procedure.

TL;DR: Modulation of ACD bioavailability may influence the addictive profile of EtOH by decreasing its psychotropic effects and possibly leading the way to new pharmacological treatments of alcoholism.