P
Patrick M. Kochanek
Researcher at University of Pittsburgh
Publications - 777
Citations - 41810
Patrick M. Kochanek is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Traumatic brain injury & Cerebral blood flow. The author has an hindex of 94, co-authored 736 publications receiving 38009 citations. Previous affiliations of Patrick M. Kochanek include National Institutes of Health & Boston Children's Hospital.
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Journal ArticleDOI
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
Michael Holzer,Fritz Sterz,J. M. Darby,S. A. Padosch,Karl B. Kern,Bernd W. Böttiger,Kees H. Polderman,Armand R. J. Girbes,Michael Holzer,Stephen Bernard,M. D. Buist,Peter Safar,Patrick M. Kochanek +12 more
TL;DR: In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.
Journal ArticleDOI
Treatment of Traumatic Brain Injury with Moderate Hypothermia
Donald W. Marion,Louis E. Penrod,Sheryl F. Kelsey,Walter Obrist,Patrick M. Kochanek,Alan M. Palmer,Stephen R. Wisniewski,Steven T. DeKosky +7 more
TL;DR: A randomized, controlled trial compared the effects of moderate hypothermia and normothermia in 82 patients with severe closed head injuries and found thatHypothermia may limit some of the deleterious metabolic responses of traumatic brain injury.
Journal ArticleDOI
Clinical trials in head injury
Raj K. Narayan,Mary Ellen Michel,Beth Ansell,Alex Baethmann,Anat Biegon,Michael B. Bracken,M. Ross Bullock,Sung C. Choi,Guy L. Clifton,Charles F. Contant,William M. Coplin,W. Dalton Dietrich,Jamshid Ghajar,Sean M. Grady,Robert G. Grossman,Edward D. Hall,William Heetderks,David A. Hovda,Jack Jallo,Russell L. Katz,Nachshon Knoller,Patrick M. Kochanek,Andrew I R Maas,Jeannine Majde,Donald W. Marion,A Marmarou,Lawrence F. Marshall,Tracy K. McIntosh,Emmy Miller,Noel Mohberg,J. Paul Muizelaar,Lawrence H. Pitts,Peter Quinn,Gad Riesenfeld,Claudia S. Robertson,Kenneth I. Strauss,Graham M. Teasdale,Nancy Temkin,Ronald F. Tuma,Charles E. Wade,Michael D. Walker,Michael Weinrich,John Whyte,Jack E. Wilberger,A. Byron Young,Lorraine Yurkewicz +45 more
TL;DR: The pathomechanisms of traumatic brain damage, based upon their clinical importance, are discussed and a uniform strategic approach for evaluation of potentially interesting new compounds in clinical trials, to ameliorate outcome in patients with severe head injury, is proposed.
Journal ArticleDOI
Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.
TL;DR: The importance of specific characteristics of a given ischemia model and of underlying stroke risk factors in determining the degree of leukocyte involvement and effectiveness of therapies directed against these cells is discussed.
Journal ArticleDOI
The far-reaching scope of neuroinflammation after traumatic brain injury
Dennis W. Simon,Mandy J. McGeachy,Hülya Bayır,Robert S. B. Clark,David J. Loane,Patrick M. Kochanek +5 more
TL;DR: A new framework of targeted immunomodulation after TBI is proposed that incorporates factors such as the time from injury, mechanism of injury, and secondary insults in considering potential treatment options and highlights findings that could offer novel therapeutic targets for translational and clinical research.