P
Paul M. Vanhoutte
Researcher at University of Hong Kong
Publications - 868
Citations - 64681
Paul M. Vanhoutte is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Endothelium & Vascular smooth muscle. The author has an hindex of 127, co-authored 868 publications receiving 62177 citations. Previous affiliations of Paul M. Vanhoutte include University of Rochester & University of Southern Denmark.
Papers
More filters
Journal ArticleDOI
Endothelium-derived relaxing and contracting factors.
TL;DR: Endothelium-dependent relaxation of blood vessels is produced by a large number of agents (e.g., acetylcholine, ATP and ADP, substance P, bradykinin, histamine, thrombin, serotonin). With some agents, relaxation may be limited to certain species and/or blood vessels as mentioned in this paper.
Journal ArticleDOI
Flow-induced release of endothelium-derived relaxing factor
TL;DR: It is demonstrated that in addition to prostacyclin, flow triggers the release of another relaxing substance (or substances) from vascular endothelial cells that has characteristics similar to the endothelium-derived relaxing factor released by acetylcholine.
Journal ArticleDOI
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor.
G. M. Rubanyi,Paul M. Vanhoutte +1 more
TL;DR: It is demonstrated that superoxide anions inactivate the relaxing factor released by acetylcholine from endothelial cells and hyperoxia favors the inactivation of endothelium-derived relaxing factor(s).
Journal Article
Endothelium-derived relaxing and contracting factors.
Paul M. Vanhoutte,Eber B +1 more
TL;DR: Endothelium‐dependent relaxation of blood vessels is produced by a large number of agents (e.g., acetylcholine, ATP and ADP, substance P, bradykinin, histamine, thrombin, serotonin).
Journal ArticleDOI
Endothelial dysfunction in diabetes
TL;DR: Correcting the principal mediators of hyperglycaemia‐induced endothelial dysfunction may be activation of protein kinase C, increased activity of the polyol pathway, non‐enzymatic glycation and oxidative stress, as well as administration of ACE inhibitors and folate has been shown to improve endothelium‐dependent vasodilation in diabetes.