Paula J. Britson

TL;DR: The approach taken in ADNI to standardization across sites and platforms of the MRI protocol, postacquisition corrections, and phantom‐based monitoring of all scanners could be used as a model for other multisite trials.

TL;DR: Although SPGR/FLASH images showed least deviation here, pulse sequence selection for the ADNI project was based on multiple additional image analyses, to be reported elsewhere.

TL;DR: Serial MRI scans can be analyzed with nonlinear image registration to relate ongoing neurodegeneration to a variety of pathological biomarkers, cognitive changes, and conversion from MCI to AD, tracking disease progression in 3-dimensional detail.

TL;DR: Compared the anatomical distribution of brain atrophy in 40 patients with Alzheimer's disease, healthy elderly controls, and individuals with amnestic mild cognitive impairment (aMCI), a condition conferring increased risk for AD, and how detection sensitivity was influenced by the sample size, the choice of search region, the initial linear registration method, and the type of TBM design is compared.

TL;DR: This work proposes a fully‐automatic method for measuring image quality of three‐dimensional (3D) structural MRI, which could greatly improve workflow through its ability to rule out the need for a repeat scan while the patient is still in the magnet bore.