P
Paulo J. Costa
Researcher at University of Lisbon
Publications - 118
Citations - 3113
Paulo J. Costa is an academic researcher from University of Lisbon. The author has contributed to research in topics: Catalysis & Halogen bond. The author has an hindex of 28, co-authored 110 publications receiving 2724 citations. Previous affiliations of Paulo J. Costa include University of California, San Diego & Instituto Nacional de Saúde Dr. Ricardo Jorge.
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Journal ArticleDOI
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets
Vera Miranda-Gonçalves,Mrinalini Honavar,Céline Pinheiro,Olga Martinho,Manuel Melo Pires,Célia Pinheiro,Michelle Cordeiro,Gil Bebiano,Paulo J. Costa,Isabel Palmeirim,Rui Manuel Reis,Fátima Baltazar +11 more
TL;DR: The MCT1 inhibitor CHC exhibited anti-tumoral and anti-angiogenic activity in gliomas and, of importance, enhanced the effect of temozolomide.
Journal ArticleDOI
A halogen-bonding catenane for anion recognition and sensing.
Journal ArticleDOI
Fluorescent Charge-Assisted Halogen-Bonding Macrocyclic Halo-Imidazolium Receptors for Anion Recognition and Sensing in Aqueous Media
Fabiola Zapata,Antonio Caballero,Nicholas G. White,Timothy D. W. Claridge,Paulo J. Costa,Vítor Félix,Paul D. Beer +6 more
TL;DR: Computational DFT and molecular dynamics simulations corroborate the experimental observations that bromo- and syn iodo-imidazoliophane XB receptors form stable cooperative convergent XB associations with bromide and iodide.
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Halogen bond anion templated assembly of an imidazolium pseudorotaxane
TL;DR: The strength of chloride-anion-templated pseudorotaxane formation with a 2-bromo-functionalized imidazolium threading component and an isophthalamide macrocycle is significantly enhanced compared to hydrogen-bonded pseudorOTaxane analogues.
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Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas
Stephen J. Moore,Cally J. E. Haynes,Jorge Gonzalez,Jorge Gonzalez,Jennifer L. Sutton,Simon J. Brooks,Mark E. Light,Julie Herniman,G. John Langley,Vanessa Soto-Cerrato,Ricardo Pérez-Tomás,Igor Marques,Paulo J. Costa,Vítor Félix,Philip A. Gale +14 more
TL;DR: Molecular dynamics simulations showed that these compounds permeate the membrane more easily than other promising receptors corroborating the experimental efflux data, and cell based assays revealed that the majority of the compounds showed cytotoxicity in cancer cells, which may be linked to their ability to function as ion transporters.