P
Per-Olof Grände
Researcher at Lund University
Publications - 120
Citations - 3812
Per-Olof Grände is an academic researcher from Lund University. The author has contributed to research in topics: Intracranial pressure & Vascular permeability. The author has an hindex of 32, co-authored 120 publications receiving 3663 citations. Previous affiliations of Per-Olof Grände include Copenhagen University Hospital.
Papers
More filters
Journal ArticleDOI
Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice
Ulrika E.A. Mårtensson,S Albert Salehi,Sara H Windahl,Maria F. Gomez,Karl Swärd,Joanna Daszkiewicz-Nilsson,Anna Wendt,Niklas Andersson,Per Hellstrand,Per-Olof Grände,Christer Owman,Clifford J. Rosen,Martin L. Adamo,Ingmar Lundquist,Patrik Rorsman,Bengt-Olof Nilsson,Claes Ohlsson,Björn Olde,L. M. Fredrik Leeb-Lundberg +18 more
TL;DR: The findings show that GPR30 is important for several metabolic functions in female mice, including estradiol-stimulated insulin release, which is associated with decreased insulin expression and release in vivo and in vitro in isolated pancreatic islets.
Journal ArticleDOI
A new therapy of post-trauma brain oedema based on haemodynamic principles for brain volume regulation.
TL;DR: The results indicate that the therapy should focus on extracellular rather than intracellular Oedema and that ischemia is not the main triggering mechanism behind oedema formation, and that the Therapy is superior to conventional therapy by preventing herniation during the healing period of the blood-brain barrier.
Journal ArticleDOI
Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation.
TL;DR: The low mortality compared with previous outcome studies strongly indicates that this therapy improves outcome for severe head injuries, however, a randomized, controlled study is needed to reach general acceptance of this new therapy.
Journal ArticleDOI
The “Lund Concept” for the treatment of severe head trauma – physiological principles and clinical application
TL;DR: The Lund Concept is an approach to the treatment of severe brain trauma that is mainly based on hypotheses originating from basic physiological principles regarding brain volume and cerebral perfusion regulation.
Journal ArticleDOI
Physiologic principles for volume regulation of a tissue enclosed in a rigid shell with application to the injured brain.
TL;DR: It is argued, in contrast to the conventional view, that antihypertensive and antistress therapy may be of value by reducing the interstitial tissue volume during treatment of brain edema, and that the problem with ischemia during such therapy can be handled when considering an otherwise optimal intensive care.