P
Peter L. Toogood
Researcher at University of Michigan
Publications - 70
Citations - 2817
Peter L. Toogood is an academic researcher from University of Michigan. The author has contributed to research in topics: Didemnin B & Guanidine. The author has an hindex of 24, co-authored 70 publications receiving 2570 citations. Previous affiliations of Peter L. Toogood include Pfizer.
Papers
More filters
Journal Article
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
David W. Fry,Patricia J. Harvey,Paul R. Keller,William Elliott,Maryanne Meade,Erin Trachet,Mudher Albassam,Xianxian Zheng,Wilbur R. Leopold,Nancy Pryer,Peter L. Toogood +10 more
TL;DR: Results indicate that inhibition of Cdk4/6 alone is sufficient to cause tumor regression and a net reduction in tumor burden in some tumors.
Journal ArticleDOI
Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists.
Xiao Hu,Yahong Wang,Ling Yang Hao,Xikui Liu,Chuck A. Lesch,Brian Sanchez,Jay M. Wendling,Rodney Morgan,Tom D. Aicher,Laura L. Carter,Peter L. Toogood,Gary D. Glick +11 more
TL;DR: During TH17 differentiation, cholesterol biosynthesis and uptake programs are induced, whereas their metabolism and efflux programs are suppressed, which results in the accumulation of the cholesterol precursor, desmosterol, which functions as a potent endogenous RORγ agonist.
Journal ArticleDOI
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4.
Scott Norman Vanderwel,Patricia J. Harvey,Dennis Joseph Mcnamara,Joseph Thomas Repine,Paul R. Keller,John Quin,R. John Booth,William Elliott,Ellen Myra Dobrusin,David W. Fry,Peter L. Toogood +10 more
TL;DR: It is reported that the introduction of a methyl substituent at the C-5 position of the pyrido[2,3-d]pyrimidin-7-one template is sufficient to confer excellent selectivity for Cdk4 vs other Cdks and representative tyrosine kinases.
Patent
2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES
Barvian Mark Robert,Booth Richard John,John Quin,Joseph Thomas Repine,Derek James Sheehan,Peter L. Toogood,Scott Norman Vanderwel,Hairong Zhou +7 more
TL;DR: In this paper, substituted 2-aminopyridines were used in treating cell proliferative disorders and they are potent inhibitors of cyclin-dependent kinases 4 ( cdk4 ).
Patent
Pteridinones as kinase inhibitors
William Alexander Denny,Gordon William Rewcastle,Dobrusin Ellen Myra,Kramer James Bernard,Dennis Joseph Mcnamara,Showalter Howard Daniel Hollis,Peter L. Toogood +6 more
TL;DR: In this article, the authors proposed a method of treating cell proliferative disorders, such as cancer and restenosis, using Formula (Ia, Ib), (Ic), (Id) wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, R2, R1, R8 is hydrogen or lower alkyl; R?4 and R6? are the same or different and represent hydrogen, halogen, lower al-kyl, lower alkoxy, (un