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Pierre Leblond
Researcher at University of Lorraine
Publications - 182
Citations - 3918
Pierre Leblond is an academic researcher from University of Lorraine. The author has contributed to research in topics: Gene & Streptomyces. The author has an hindex of 34, co-authored 157 publications receiving 3387 citations. Previous affiliations of Pierre Leblond include Institut national de la recherche agronomique & Nancy-Université.
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Journal ArticleDOI
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Luisa Laureti,Lijiang Song,Sheng Huang,Sheng Huang,Christophe Corre,Pierre Leblond,Gregory L. Challis,Bertrand Aigle +7 more
TL;DR: The Stambomycins A-D gene cluster as mentioned in this paper is one of the largest polyketide biosynthetic gene clusters described to date, which is composed of 25 genes (nine of which encode PKSs).
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Physical map of the Streptomyces lividans 66 genome and comparison with that of the related strain Streptomyces coelicolor A3(2).
TL;DR: A physical map of the chromosome of Streptomyces lividans 66 ZX7 was constructed by ordering the macrorestriction fragments generated from the genomic DNA with the restriction enzymes AseI and DraI, revealing a common structure with an identical ordering of the cosmid sequences.
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Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.
Francisco Barona-Gómez,Sylvie Lautru,François-Xavier Francou,Pierre Leblond,Jean-Luc Pernodet,Gregory L. Challis +5 more
TL;DR: It is shown that coelichelin and desferrioxamines E and B all function as siderophores in this organism and that at least one of these metabolites is required for growth under defined conditions even in the presence of significant quantities of ferric iron.
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The unstable region of Streptomyces ambofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA.
Pierre Leblond,Gilles Fischer,François-Xavier Francou,Franca Berger,Michel Guerineau,Bernard Decaris +5 more
TL;DR: Physical maps of the chromosomes of three strains of Streptomyces ambofaciens were constructed by ordering AseI fragments generated from the genomic DNA as a single linear chromosome of about 8 Mb, which corresponds to the longest terminal inverted repeats so far characterized.
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Evolution of the Terminal Regions of the Streptomyces Linear Chromosome
Frédéric Choulet,Bertrand Aigle,Alexandre Gallois,Sophie Mangenot,Claude Gerbaud,Chantal Truong,François-Xavier Francou,Céline Fourrier,Michel Guerineau,Bernard Decaris,Valérie Barbe,Jean-Luc Pernodet,Pierre Leblond +12 more
TL;DR: It is speculated that a gradient of recombination rate toward the extremities is the force driving the exclusion of essential genes from the terminal regions (i.e., chromosome compartmentalization) and generating a fast gene turnover for strong adaptation capabilities.