P
Prakash S. Nagarkatti
Researcher at University of South Carolina
Publications - 369
Citations - 15288
Prakash S. Nagarkatti is an academic researcher from University of South Carolina. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 62, co-authored 341 publications receiving 12650 citations. Previous affiliations of Prakash S. Nagarkatti include Virginia Tech & University of Kentucky.
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Journal Article
Role of cytokines as a double-edged sword in sepsis.
Hina Chaudhry,Juhua Zhou,Juhua Zhou,Yin Zhong,Mir Mustafa Ali,Franklin R. McGuire,Prakash S. Nagarkatti,Mitzi Nagarkatti +7 more
TL;DR: A decrease in IL-6 was associated with a better prognosis and overproduction of IL-10 was found to be the main predictor of severity and fatal outcome, indicating pro-inflammatory and anti-inflammatory cytokines constitute a double-edged sword in sepsis.
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Cannabinoids as novel anti-inflammatory drugs
Prakash S. Nagarkatti,Rupal Pandey,Sadiye Amcaoglu Rieder,Venkatesh L. Hegde,Mitzi Nagarkatti +4 more
TL;DR: This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components.
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Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
Robert J. McKallip,Catherine Lombard,Michael T. Fisher,Billy R. Martin,Seonho Ryu,Steven Grant,Prakash S. Nagarkatti,Mitzi Nagarkatti +7 more
TL;DR: The current data demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of apoptosis, and because CB2 agonists lack psychotropic effects, they may Serve as novel anticancer agents to selectively target and kill tumors of immune origin.
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Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis.
Narendra P. Singh,Udai P. Singh,Balwan Singh,Robert L. Price,Mitzi Nagarkatti,Prakash S. Nagarkatti +5 more
TL;DR: These studies demonstrate for the first time that AhR activation promotes epigenetic regulation thereby influencing reciprocal differentiation of Tregs and Th17 cells, and amelioration of inflammation.
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Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis
Liang Qiao,Elaine Studer,Kevin Leach,Robert McKinstry,Seema Gupta,Roy H. Decker,Rakesh C. Kukreja,Kristoffer Valerie,Prakash S. Nagarkatti,Wafik El Deiry,Jeffrey D. Molkentin,Rupert Schmidt-Ullrich,Paul B. Fisher,Steven Grant,Philip B. Hylemon,Paul Dent +15 more
TL;DR: The data argues that DCA is causing ligand independent activation of the FAS receptor to stimulate an apoptotic response, which is counteracted by enhanced ligand-independent EGFR/MAPK signaling, which potentiates DCA-stimulated FAS-induced hepatocyte cell death via a reduction in the expression of c-FLIP isoforms.