Raphael M. Bonelli

TL;DR: This paper presents the three main frontal-subcortical circuits: the dorsolateral prefrontal circuit allows the organization of information to facilitate a response; the anterior cingulate circuit is required for motivated behavior; and the orbitofrontal circuit allowing the integration of limbic and emotional information into behavioral responses.

TL;DR: There is good evidence that religious involvement is correlated with better mental health in the areas of depression, substance abuse, and suicide; some evidence in stress-related disorders and dementia; insufficient evidence in bipolar disorder and schizophrenia; and no data in many other mental disorders.

TL;DR: A novel measure of disease progression and a genome-wide significant signal on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2 is generated, suggesting this mechanism as an area for future therapeutic investigation.

TL;DR: Depression, irritability/aggression and OCBs are prevalent in all stages of HD, and apathy was the key neuropsychiatric symptom occurring most often in advanced HD stages.

TL;DR: There is poor evidence in management of HD today and the analysis of the twenty level-I studies fails to result in any treatment recommendation of clinical relevance, so high-quality RCT are highly warranted to advance HD treatment in clinical practice.