R
Regina M. Botting
Researcher at Queen Mary University of London
Publications - 44
Citations - 9107
Regina M. Botting is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Cyclooxygenase & Mechanism of action. The author has an hindex of 25, co-authored 44 publications receiving 8770 citations. Previous affiliations of Regina M. Botting include St Bartholomew's Hospital.
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Regulatory functions of the vascular endothelium.
TL;DR: The vascular endothelium, which envelops the circulating blood in a continuous monolayer, is mainly responsible for this function, but over the past 20 years numerous other important functions have been discovered.
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Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
TL;DR: Characterization of the two COX isozymes is allowing the discrimination of the roles each play in physiological processes such as homeostatic maintenance of the gastrointestinal tract, renal function, blood clotting, embryonic implantation, parturition, pain, and fever.
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New insights into the mode of action of anti-inflammatory drugs
John R. Vane,Regina M. Botting +1 more
TL;DR: The constitutive cyclooxygenase-1 (COX-1) can thus be considered a “housekeeping” enzyme, in contrast to cyclo oxygenogenase-2 ( COX-2) which is activated by tissue damage.
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Anti-inflammatory drugs and their mechanism of action
John R. Vane,Regina M. Botting +1 more
TL;DR: Selective COX-2 inhibitors may demonstrate new important therapeutic benefits as anticancer agents, as well as in preventing premature labor and perhaps even retarding the progression of Alzheimer's disease.
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Mechanism of action of nonsteroidal anti-inflammatory drugs.
John R. Vane,Regina M. Botting +1 more
TL;DR: It is attractive to suggest that the anti-inflammatory actions of NSAIDs are due to inhibition of COX-2, whereas the unwanted side-effects, such as irritation of the stomach lining, are dueto inhibition ofCOX-1.