Richard J. Jones

TL;DR: The copper chelator tetraethylenepentamine (TEPA; StemEx) was shown to attenuate the differentiation of ex vivo cultured hematopoietic cells resulting in preferential expansion of early progenitors resulting in 100-day survival and this strategy is feasible.

TL;DR: It is reported here that NADPH oxidase, an enzyme complex required for the normal antibacterial function of white blood cells, is the main target of arsenic-induced ROS production, and a synergism between arsenic and the clinically used phorbol myristate acetate analog, bryostatin 1, can be expected.

TL;DR: Cotreatment with low doses of oligoamines and a DNA methyltransferase inhibitor highly induces the reexpression of the aberrantly silenced SFRP2 gene and results in significant inhibition of the growth of established tumors in a human colon tumor model in vivo.

TL;DR: Data support the hypothesis that signaling through the IGF-1/IGF-1R axis contributes to acquired bortezomib resistance, and provide a rationale for combining bortazomib with IGF- 1R inhibitors like OSI-906 to overcome or possibly prevent the emergence of bortzomib-refractory disease in the clinic.

TL;DR: Primitive hematopoietic cells appear to be intrinsically programmed to undergo RA-mediated differentiation unless prevented from doing so by bone marrow niche CYP26, andModulation of RA signaling also holds promise for clinical HSC expansion, a prerequisite for the wide-scale use of these cells in regenerative medicine and gene therapy.