Sarah C. Jernigan

TL;DR: It is reported that resveratrol binds ERb and ERa with comparable affinity, but with 7,000-fold lower affinity than estradiol (E2), which indicates that those tissues that uniquely express ERb or that express higher levels of ERb than ERa may be more sensitive to resver atrol’s estrogen agonist activity.

TL;DR: These Guidelines are distributed with the understanding that the Brain Trauma Foundation, the National Highway Traffic Safety Administration, and the other organizations that have collaborated in the development of these Guidelines are not engaged in rendering professional medical services.

TL;DR: Testing the hypothesis that alterations in ER conformation induced by binding to different ERE sequences modulates ER interaction with coactivators and corepressors demonstrated that the ERE sequence impacts estradiol-and 4-hydroxytamoxifen-occupied ERalpha and ERbeta interaction with coregulators as measured by transcriptional activity in mammalian cells.

TL;DR: The results support the hypothesis that the ERE sequence acts as an allosteric effector, altering ER conformation, and speculate that ERE-induced alterations in ERalpha conformation modulate interaction with co-regulatory proteins.

TL;DR: In RL95-2 human endometrial carcinoma cells, SHP inhibited TCDD-stimulated reporter activity from the AHR-responsive CYP1A1 and UGT1A6 gene promoters in a concentration-dependent manner and identified ARNT as a novel SHP target.