S
Sean X. Leng
Researcher at Johns Hopkins University School of Medicine
Publications - 91
Citations - 6723
Sean X. Leng is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medicine & Vaccination. The author has an hindex of 37, co-authored 77 publications receiving 5402 citations. Previous affiliations of Sean X. Leng include Johns Hopkins University & University of Connecticut Health Center.
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Journal ArticleDOI
Frailty syndrome: an overview
TL;DR: Frailty is a common and important geriatric syndrome characterized by age-associated declines in physiologic reserve and function across multiorgan systems, leading to increased vulnerability for adverse health outcomes, including obesity and specific diseases.
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Aging in COVID-19: Vulnerability, immunity and intervention.
Yiyin Chen,Sabra L. Klein,Brian T. Garibaldi,Huifen Li,Cunjin Wu,Nicole M. Osevala,Taisheng Li,Joseph B. Margolick,Graham Pawelec,Sean X. Leng +9 more
TL;DR: It is hypothesized that age-related decline and dysregulation of immune function, i.e., immunosenescence and inflammaging play a major role in contributing to heightened vulnerability to severe COVID-19 outcomes in older adults and partitioning all immunological outcome data by age to better understand disease heterogeneity and aging.
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ELISA and multiplex technologies for cytokine measurement in inflammation and aging research.
Sean X. Leng,Janet E. McElhaney,Janet E. McElhaney,Jeremy D. Walston,Dongxu Xie,Neal S. Fedarko,George A. Kuchel +6 more
TL;DR: This article reviews ELISA and the emerging multiplex technologies, compares the cost and effectiveness of recently developed multiplex arrays with traditional ELISA technology, and provides specific recommendations for investigators interested in measuring serum inflammatory mediators in older adults.
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Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment
Linda P. Fried,Qian Li Xue,Anne R. Cappola,Luigi Ferrucci,Paulo H.M. Chaves,Ravi Varadhan,Jack M. Guralnik,Sean X. Leng,Richard D. Semba,Jeremy D. Walston,Caroline S. Blaum,Caroline S. Blaum,Karen Bandeen-Roche +12 more
TL;DR: It is shown that a threshold loss of complexity, as indicated by number of systems abnormal, may undermine homeostatic adaptive capacity, leading to the development of frailty and its associated risk for subsequent adverse outcomes.
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Inflammation and Frailty in Older Women
TL;DR: To evaluate relationships between white blood cell (WBC) count and interleukin‐6 (IL‐6) and prevalent frailty, a large number of animals were vaccinated for WBC and IL‐6 infection.