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Seung-Jae Lee

Researcher at KAIST

Publications -  176
Citations -  6474

Seung-Jae Lee is an academic researcher from KAIST. The author has contributed to research in topics: Caenorhabditis elegans & Longevity. The author has an hindex of 34, co-authored 158 publications receiving 5321 citations. Previous affiliations of Seung-Jae Lee include University of the Sciences & Pohang University of Science and Technology.

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Journal ArticleDOI

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Malene Hansen, +5 more
- 01 Feb 2007 - 
TL;DR: These findings link TOR, but not sir‐2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis.
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Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

Seung-Jae Lee, +2 more
- 07 Dec 2010 - 
TL;DR: It is found that ROS are increased in respiration mutants and that mild increases in ROS can stimulate HIF-1 to activate gene expression and promote longevity, which appears to link respiratory stress in the mitochondria to a nuclear transcriptional response that promotes longevity.
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Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.

Seung-Jae Lee, +2 more
- 04 Nov 2009 - 
TL;DR: It is shown that changes in glycerol metabolism are likely to underlie the life span-shortening effect of glucose and that aqp-1 may act cell nonautonomously as a feedback regulator in the insulin/IGF-1-signaling pathway.
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OASIS: online application for the survival analysis of lifespan assays performed in aging research.

Jae-Seong Yang, +7 more
- 15 Aug 2011 - 
TL;DR: An online application for survival analysis (OASIS) that helps conduct various novel statistical tasks involved in analyzing survival data in a user-friendly manner and provides statistical methods that can analyze variances among survival datasets.
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OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

Seong Kyu Han, +7 more
- 12 Aug 2016 - 
TL;DR: OASIS 2 enables the statistical comparison of maximal lifespans, which is potentially useful for determining key factors that limit the lifespan of a population and provides statistical and graphical tools that compare values in different conditions and times.