Shaolian Zhou

TL;DR: It is found that H3K4me3 inhibits PRC2 activity in an allosteric fashion assisted by the Su(z)12 C terminus, which provides the molecular basis of histone H3 N terminus recognition by thePRC2 Nurf55-Su( z)12 submodule.

TL;DR: EED226 is reported, a potent and selective PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED, and shows similar activity to SAM-competitive inhibitors in blocking H 3K27 methylation ofPRC2 target genes and inducing regression of human lymphoma xenograft tumors.

TL;DR: The results suggest that it is unlikely that the entire Abeta sequence is involved in H-bonded secondary structure within the amyloid fibril, and further studies using the methods described here should reveal further details of Abeta fibrils structure and assembly.

TL;DR: Study of the dependence of ionization of the weak base caffeine on the electrospray capillary potential reveals three distinct contributors to wrong-way-round ionization.

TL;DR: Transfer RNAs from Methanococci, a lineage of methanogenic marine euryarchaea that grow over an unusually broad temperature range, were studied to determine whether modification patterns reflect the close phylogenetic relationships inferred from small ribosomal subunit RNA sequences, and to examine modification differences associated with temperature of growth.