S
Shen Shen
Researcher at University of North Carolina at Chapel Hill
Publications - 22
Citations - 2513
Shen Shen is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Transduction (genetics) & Gene. The author has an hindex of 13, co-authored 21 publications receiving 1936 citations. Previous affiliations of Shen Shen include Saint Louis University & Salk Institute for Biological Studies.
Papers
More filters
Journal ArticleDOI
NF-κB, an Active Player in Human Cancers
TL;DR: Because of its vital role in various biologic activities, components of the NF-κB pathway need to be carefully selected and evaluated to design targeted therapies.
Journal ArticleDOI
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10.
Morgan L. Maeder,Michael Stefanidakis,Christine D. Wilson,Reshica Baral,Luis A. Barrera,George S. Bounoutas,David Bumcrot,Hoson Chao,Dawn Ciulla,Jennifer A. DaSilva,Abhishek Dass,Vidya Dhanapal,Timothy Fennell,Ari E. Friedland,Georgia Giannoukos,Sebastian Gloskowski,Alexandra Glucksmann,Gregory Gotta,Hariharan Jayaram,Scott Haskett,Bei Hopkins,Joy E. Horng,Shivangi Joshi,Eugenio Marco,Rina Mepani,Deepak Reyon,Terence Ta,Diana Tabbaa,Steven J. Samuelsson,Shen Shen,Maxwell N. Skor,Pam Stetkiewicz,Tongyao Wang,Clifford Yudkoff,Vic E. Myer,Charles F Albright,Haiyan Jiang +36 more
TL;DR: In human cells, a humanized mouse model and non-human primates, CRISPR/Cas9 corrects the splicing defect in a gene associated with congenital blindness.
Journal ArticleDOI
Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
Ari E. Friedland,Reshica Baral,Pankhuri Singhal,Katherine Loveluck,Shen Shen,Minerva E Sanchez,Eugenio Marco,Gregory Gotta,Morgan L. Maeder,Edward M. Kennedy,Anand V.R. Kornepati,Alexander Sousa,McKensie Collins,Hari Jayaram,Bryan R. Cullen,David Bumcrot +15 more
TL;DR: The results reveal an S. aureus Cas9 that is effective for a variety of genome engineering purposes, including paired nickase approaches and all-in-one delivery of Cas9 and multiple gRNA expression cassettes with AAV vectors.
Journal ArticleDOI
Terminal N-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9
TL;DR: Treatment of well differentiated human airway epithelial cultures and intranasal instillation of recombinant sialidase in murine airways enhanced transduction efficiency of AAV9 by >1 order of magnitude, and a biochemical strategy to enhance gene transfer by A AV9 vectors in general is proposed.
Journal ArticleDOI
Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer.
Nagesh Pulicherla,Shen Shen,Swati Yadav,Kari Debbink,Lakshmanan Govindasamy,Mavis Agbandje-McKenna,Aravind Asokan +6 more
TL;DR: L Liver-detargeted AAV9 variants described herein are excellent candidates for preclinical evaluation in animal models of cardiac and musculoskeletal disease and when combined with other targeting strategies could allow sharply segregated gene expression.