S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Negative inotropic effects of cytokines on the heart mediated by nitric oxide
Mitchell S. Finkel,Carmine V. Oddis,Timothy D. Jacob,Simon C. Watkins,Brack G. Hattler,Richard L. Simmons +5 more
TL;DR: The findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase, and the regulation of pro-inflammatory cytokines and myocardia nitricoxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Valerian E. Kagan,Gaowei Mao,Feng Qu,José Pedro Friedmann Angeli,Sebastian Doll,Claudette M. St. Croix,Haider H. Dar,Bing Liu,Vladimir A. Tyurin,Vladimir B. Ritov,Alexandr A. Kapralov,Andrew A. Amoscato,Jianfei Jiang,Tamil S. Anthonymuthu,Dariush Mohammadyani,Qin Yang,Bettina Proneth,Judith Klein-Seetharaman,Simon C. Watkins,Ivet Bahar,Joel S. Greenberger,Rama K. Mallampalli,Brent R. Stockwell,Yulia Y. Tyurina,Marcus Conrad,Hülya Bayır +25 more
TL;DR: It is discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one class of phospholipids (phosphatidylethanolamines (PEs) and is specific toward two fatty acyls-arachidonoyl (AA) and AdA (AdA).
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Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
Angela Montecalvo,Adriana T. Larregina,William J. Shufesky,Donna B. Stolz,Mara Sullivan,Jenny Karlsson,Catherine J. Baty,Gregory A. Gibson,Geza Erdos,Zhiliang Wang,Jadranka Milosevic,Olga A. Tkacheva,Sherrie J. Divito,Rick Jordan,James Lyons-Weiler,Simon C. Watkins,Adrian E. Morelli +16 more
TL;DR: It is demonstrated that DCs release exosomes with different miRNAs depending on the maturation of the DCs, and exosome-shuttle miRNAAs are functional, because they repress target mRNAs of acceptor DCs.
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Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes
TL;DR: Skeletal muscle of trained endurance athletes is markedly insulin sensitive and has a high oxidative capacity, despite having an elevated lipid content, according to quantitative image analysis of Oil Red O staining.
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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.
Adrian E. Morelli,Adriana T. Larregina,William J. Shufesky,Mara Sullivan,Donna B. Stolz,Glenn D. Papworth,Alan F. Zahorchak,Alison J. Logar,Zhiliang Wang,Simon C. Watkins,Louis D. Falo,Angus W. Thomson +11 more
TL;DR: It is demonstrated that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells, implying that exOSomes present in circulation or extracellular fluids constitute an alternative source of self- or allopeptides for DCs during maintenance of peripheral tolerance or initiation of the indirect pathway of allorecognition in transplantation.