S
Sneha S. Kelkar
Researcher at Wake Forest University
Publications - 23
Citations - 1373
Sneha S. Kelkar is an academic researcher from Wake Forest University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 14 publications receiving 1188 citations. Previous affiliations of Sneha S. Kelkar include Wake Forest Institute for Regenerative Medicine & Virginia Tech.
Papers
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Journal ArticleDOI
Theranostics: Combining Imaging and Therapy
TL;DR: The creative approaches being developed for these classes of therapies and imaging modalities are discussed, and the recent developments along with examples of technologies that hold promise for the future of cancer medicine are highlighted.
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Indocyanine Green-Loaded Nanoparticles for Image-Guided Tumor Surgery
Tanner K. Hill,Asem I. Abdulahad,Sneha S. Kelkar,Frank C. Marini,Timothy Edward Long,James M. Provenzale,Aaron M. Mohs +6 more
TL;DR: A series of hyaluronic acid-derived nanoparticles that entrap the near-infrared dye indocyanine green, termed NanoICG, for improved delivery of the dye to tumors and was found to be nontoxic at physiologically relevant concentrations and exposure was not found to inhibit cell growth.
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Near Infrared Fluorescent Nanoparticles Derived from Hyaluronic Acid Improve Tumor Contrast for Image-Guided Surgery
Tanner K. Hill,Sneha S. Kelkar,Nicholas E. Wojtynek,Joshua J. Souchek,William M. Payne,Kristina Stumpf,Frank C. Marini,Aaron M. Mohs +7 more
TL;DR: The efficacy of a panel of HA-derived NPs in delineating tumors in vivo is demonstrated, and promising formulations that can be used for future in vivo tumor removal efficacy studies are identified.
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Near infrared fluorescent nanoparticles based on hyaluronic acid: Self-assembly, optical properties, and cell interaction
TL;DR: It is shown that the impact of HA molecular weight and the hydrophobic moiety conjugation degree on fluorescence and cell interaction can be predicted and lay the foundation for selection of optimized HA-derived NPs for image-guided surgery.
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Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines
Tanner K. Hill,Amanda L. Davis,Frances B. Wheeler,Sneha S. Kelkar,Erica Freund,W. Todd Lowther,Steven J. Kridel,Aaron M. Mohs +7 more
TL;DR: NP formulation of ORL using HA-derived polymers retains similar levels of FASN, lipid synthesis, and ATP turnover inhibition while significantly improving the cytotoxic activity against cancer cell lines.