Stephen J. W. Evans

TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.

TL;DR: An updated extension of the CONSORT checklist for reporting noninferiority and equivalence trials is presented, based on the 2010 version of theconsORT Statement and the 2008 CONSORT Statement for the reporting of abstracts, and illustrative examples and explanations for those items that differ from the main 2010consORT checklist are provided.

TL;DR: This work searched MEDLINE, EMBASE, Web of Science, and the Cochrane Library using a wide array of terms related to harms and identified pertinent evidence and made recommendations on the appropriate reporting of harms in RCTs.

TL;DR: The large-scale evidence from randomised trials indicates that it is unlikely that large absolute excesses in other serious adverse events still await discovery, and any further findings that emerge about the effects of statin therapy would not be expected to alter materially the balance of benefits and harms.

TL;DR: The process of generating ‘signals’ of possible unrecognized hazards from spontaneous adverse drug reaction reporting data has been likened to looking for a needle in a haystack but statistical approaches to the data have been underutilised.