S
Stephen Lyle
Researcher at University of Massachusetts Medical School
Publications - 92
Citations - 5124
Stephen Lyle is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Stem cell & Cancer. The author has an hindex of 36, co-authored 89 publications receiving 4567 citations. Previous affiliations of Stephen Lyle include Beth Israel Deaconess Medical Center & Pfizer.
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Journal ArticleDOI
Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge
TL;DR: It is found that patterns of K15 expression and promoter activity changed with age and correlated with levels of differentiation within the cutaneous epithelium; less differentiated keratinocytes in the epidermis of the neonatal mouse and in the bulge area of the adult mouse preferentially expressed K15.
Journal ArticleDOI
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Joshua C. Doloff,Joshua C. Doloff,Minglin Ma,Minglin Ma,Minglin Ma,Hok Hei Tam,Kaitlin M. Bratlie,Kaitlin M. Bratlie,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Erin Langan,Erin Langan,Karsten Olejnik,Karsten Olejnik,Patrick Fenton,Patrick Fenton,Jeon Woong Kang,Jennifer Hollister-Locke,Matthew A. Bochenek,Alan Chiu,Alan Chiu,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Thema Vietti,Thema Vietti,Michael Chen,Michael Chen,Josh Cohen,Karolina Siniakowicz,Meirigeng Qi,James J. McGarrigle,Stephen Lyle,David M. Harlan,Dale L. Greiner,Jose Oberholzer,Gordon C. Weir,Robert Langer,Robert Langer,Daniel G. Anderson,Daniel G. Anderson +55 more
TL;DR: This article used a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate.
Journal ArticleDOI
Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance
Nathan Moore,Stephen Lyle +1 more
TL;DR: The evidence for quiescent CSC populations is reviewed and potential cell cycle regulators that may serve as future targets for elimination of these cells are explored.
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Joshua C. Doloff,Joshua C. Doloff,Minglin Ma,Minglin Ma,Minglin Ma,Hok Hei Tam,Kaitlin M. Bratlie,Kaitlin M. Bratlie,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Erin Langan,Erin Langan,Karsten Olejnik,Karsten Olejnik,Patrick Fenton,Patrick Fenton,Jeon Woong Kang,Jennifer Hollister-Locke,Matthew A. Bochenek,Alan Chiu,Alan Chiu,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Thema Vietti,Thema Vietti,Michael Chen,Michael Chen,Josh Cohen,Karolina Siniakowicz,Meirigeng Qi,James J. McGarrigle,Stephen Lyle,David M. Harlan,Dale L. Greiner,Jose Oberholzer,Gordon C. Weir,Robert Langer,Robert Langer,Daniel G. Anderson,Daniel G. Anderson +55 more
TL;DR: A combinatorial approach for covalent chemical modification is used to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate, and identifies three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates.
Journal ArticleDOI
Development of a Prognostic Genetic Signature to Predict the Metastatic Risk Associated with Cutaneous Melanoma
Pedram Gerami,Robert W. Cook,Jeffrey Wilkinson,Maria C. Russell,Navneet Dhillon,Rodabe N. Amaria,Rene Gonzalez,Stephen Lyle,Clare Johnson,Kristen M. Oelschlager,Gilchrist L. Jackson,Anthony Greisinger,Derek Maetzold,Keith A. Delman,David H. Lawson,John F. Stone +15 more
TL;DR: The GEP signature accurately predicts metastasis risk in a multicenter cohort of primary cutaneous melanoma tumors and preliminary Cox regression analysis indicates that the signature is an independent predictor of metastatic risk in the cohort presented.