S
Stuart McPherson
Researcher at Newcastle upon Tyne Hospitals NHS Foundation Trust
Publications - 139
Citations - 5903
Stuart McPherson is an academic researcher from Newcastle upon Tyne Hospitals NHS Foundation Trust. The author has contributed to research in topics: Medicine & Fatty liver. The author has an hindex of 27, co-authored 106 publications receiving 4277 citations. Previous affiliations of Stuart McPherson include University of Newcastle & National Health Service.
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Journal ArticleDOI
Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
Stuart McPherson,Stuart McPherson,Timothy Hardy,E Henderson,Alastair D. Burt,Alastair D. Burt,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +9 more
TL;DR: Contrary to current dogma, this study suggests that steatosis can progress to NASH and clinically significant fibrosis.
Journal ArticleDOI
Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease
TL;DR: The ALT/AST ratio, FIB-4 and NAFLD fibrosis scores can reliably exclude advanced fibrosis in a high proportion of patients with non-alcoholic fatty liver disease, allowing liver biopsy to be used in a more directed manner.
Journal ArticleDOI
Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Rod S Taylor,Rebecca J. Taylor,Susan Bayliss,Hannes Hagström,Patrik Nasr,Jörn M. Schattenberg,Masatoshi Ishigami,Hidenori Toyoda,Vincent Wai-Sun Wong,Noam Peleg,Amir Shlomai,Giada Sebastiani,Yuya Seko,Neeraj Bhala,Zobair M. Younossi,Quentin M. Anstee,Quentin M. Anstee,Stuart McPherson,Stuart McPherson,Philip N. Newsome,Philip N. Newsome +20 more
TL;DR: Biopsy-confirmed fibrosis is found to be associated with risk of mortality and liver-related morbidity in patients with NAFLD, with and without adjustment for confounding factors and in Patients with reported NASH.
Journal ArticleDOI
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Yang-Lin Liu,Helen L. Reeves,Alastair D. Burt,Dina Tiniakos,Stuart McPherson,Julian B. S. Leathart,Michael Allison,Graeme J.M. Alexander,Anne Christine Piguet,Rodolphe Anty,Peter T. Donaldson,Guruprasad P. Aithal,Sven Francque,Luc Van Gaal,Karine Clément,Vlad Ratziu,Jean-François Dufour,Christopher P. Day,Ann K. Daly,Quentin M. Anstee +19 more
TL;DR: It is confirmed that TM6SF2 minor allele carriage is associated with NAFLD and is causally related to a previously reported chromosome 19 GWAS signal that was ascribed to the gene NCAN.
Journal ArticleDOI
Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
Stuart McPherson,Stuart McPherson,Timothy Hardy,Timothy Hardy,Jean-François Dufour,Salvatore Petta,Manuel Romero-Gómez,M. Allison,Claudia P. Oliveira,Sven Francque,Luc Van Gaal,Jörn M. Schattenberg,Dina Tiniakos,Dina Tiniakos,Alastair D. Burt,Elisabetta Bugianesi,Vlad Ratziu,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +20 more
TL;DR: The NFS and FIB-4 scores have similar accuracy for advanced fibrosis in patients aged >35 years, however, the specificity forAdvanced fibrosis is unacceptably low in patients ages aged ≥65 years, resulting in a high false positive rate.