S
Sudeep Banjade
Researcher at Cornell University
Publications - 19
Citations - 3781
Sudeep Banjade is an academic researcher from Cornell University. The author has contributed to research in topics: ESCRT & Endosome. The author has an hindex of 8, co-authored 18 publications receiving 2584 citations. Previous affiliations of Sudeep Banjade include Johns Hopkins University School of Medicine & Howard Hughes Medical Institute.
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Journal ArticleDOI
Phase transitions in the assembly of multivalent signalling proteins
Pilong Li,Sudeep Banjade,Hui-Chun Cheng,Soyeon Kim,Baoyu Chen,Liang Guo,Marc C. Llaguno,Javoris Hollingsworth,David S. King,Salman F. Banani,Paul S. Russo,Qiu-Xing Jiang,B. Tracy Nixon,Michael K. Rosen +13 more
TL;DR: Interactions between diverse synthetic, multivalent macromolecules (including multi-domain proteins and RNA) produce sharp liquid–liquid-demixing phase separations, generating micrometre-sized liquid droplets in aqueous solution.
Journal ArticleDOI
Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su,Xiaolei Su,Jonathon A. Ditlev,Jonathon A. Ditlev,Enfu Hui,Enfu Hui,Wenmin Xing,Wenmin Xing,Sudeep Banjade,Sudeep Banjade,Julia Okrut,Julia Okrut,David S. King,Jack Taunton,Jack Taunton,Michael K. Rosen,Michael K. Rosen,Ronald D. Vale,Ronald D. Vale +18 more
TL;DR: It is demonstrated that protein phase separation can create a distinct physical and biochemical compartment that facilitates signaling and promote signaling outputs both in vitro and in human Jurkat T cells.
Journal ArticleDOI
Phase transitions of multivalent proteins can promote clustering of membrane receptors
Sudeep Banjade,Michael K. Rosen +1 more
TL;DR: Biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck and N-WASP is reported, suggesting that clustering of regulatory factors could promote local actin assembly at membranes.
Journal ArticleDOI
Computed structures of core eukaryotic protein complexes.
Ian R. Humphreys,Jimin Pei,Minkyung Baek,Aditya Krishnakumar,Ivan Anishchenko,Sergey Ovchinnikov,Jing Zhang,Travis J. Ness,Sudeep Banjade,Saket R. Bagde,Viktoriya G. Stancheva,Xiao-Han Li,Kaixian Liu,Zhi Zheng,Zhi Zheng,Daniel J. Barrero,Upasana Roy,Jochen Kuper,Israel S. Fernández,Barnabas Szakal,Dana Branzei,Josep Rizo,Caroline Kisker,Eric C. Greene,Sue Biggins,Scott Keeney,Scott Keeney,Elizabeth A. Miller,J. Christopher Fromme,Tamara L. Hendrickson,Qian Cong,David Baker +31 more
TL;DR: The structures of many eukaryotic protein complexes are unknown, and there are likely many protein-protein interactions not yet identified as mentioned in this paper, but these structures play critical roles in biology.
Journal ArticleDOI
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Chen Qiu,Mary Katherine Tarrant,Sung Hee Choi,Aruna Sathyamurthy,Ron Bose,Sudeep Banjade,Ashutosh Pal,William G. Bornmann,Mark A. Lemmon,Philip A. Cole,Daniel J. Leahy +10 more
TL;DR: Crystal structures of the ErbBB4 kinase domain in active and lapatinib-inhibited forms are reported to demonstrate that key elements of kinase activation and inhibition are conserved among Erb B family members.