Sudipa Saha Roy

TL;DR: A review summarizes the emerging role of ER signaling in promoting metastasis of breast cancer cells, discusses the molecular mechanisms by which ER signaling contributes to metastasis, and explores possible therapeutic targets to block ER-driven metastasis.

TL;DR: It is shown that PELP1 modulates expression of metastasis-influencing microRNAs (miRs) to promote cancer metastasis and regulates their expression by recruiting chromatin modifier histone deacetylase 2 (HDAC2) as revealed by chromatin immunoprecipitation, small interfering RNA and HDAC inhibitor assays.

TL;DR: The efficacy of five naturally occurring flavonoids in arresting the development of anemia during the postinfection period is revealed and quercetin was most successful in inhibiting the oxidation of proteins and lipids on the red cell membranes of infected animals.

TL;DR: This research may eventually evolve a product platform with reduced systemic toxicity inherent with traditional chemotherapy and localized toxicity inherent to single-target nanoplatforms, thereby allowing for better tolerance of higher therapeutic load in advanced disease states.

TL;DR: This work identifies tatn-1, which is the worm ortholog of tyrosine aminotransferase and catalyzes the first step of the conserved tyrosinesine degradation pathway, as a novel regulator of the dauer decision and modulator of thedaf-2 insulin/IGF-1-like (IGFR) signaling pathway in Caenorhabditis elegans, and finds that the controlled metabolism of tyrose may function normally in dauer