S
Suzanne M. de la Monte
Researcher at Brown University
Publications - 17
Citations - 3814
Suzanne M. de la Monte is an academic researcher from Brown University. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 13, co-authored 17 publications receiving 3259 citations. Previous affiliations of Suzanne M. de la Monte include Rhode Island Hospital.
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Journal ArticleDOI
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
Eric J. Steen,Benjamin M. Terry,Enrique J. Rivera,Jennifer L. Cannon,Thomas R. Neely,Rose Tavares,X. Julia Xu,Jack R. Wands,Suzanne M. de la Monte +8 more
TL;DR: The present work demonstrates extensive abnormalities in insulin and insulin-like growth factor type I and II (IGF-I and IGF-II) signaling mechanisms in brains with AD, and shows that while each of the corresponding growth factors is normally made in central nervous system neurons, the expression levels are markedly reduced in AD.
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Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
TL;DR: The term “type 3 diabetes” accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM.
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Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer's Disease
TL;DR: The contributions of impaired insulin and IGF signaling to AD-associated neuronal loss, synaptic disconnection, tau hyperphosphorylation, amyloid-beta accumulation, and impaired energy metabolism are reviewed and current therapeutic strategies are discussed.
Journal ArticleDOI
Brain metabolic dysfunction at the core of Alzheimer's disease
Suzanne M. de la Monte,Ming Tong +1 more
TL;DR: Brain insulin/IGF resistance and its consequences can readily account for most of the structural and functional abnormalities in AD, and epidemiologic data suggest that insulin resistance diseases, including AD, are exposure-related in etiology.
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Human alcohol-related neuropathology
TL;DR: Further progress is needed to better understand the pathophysiology of this exposure-related constellation of nervous system diseases and better correlate the underlying pathology with in vivo imaging and biochemical lesions.