Theodore W. Zderic

TL;DR: There is an emergence of inactivity physiology studies beginning to raise a new concern with potentially major clinical and public health significance: the average nonexercising person may become even more metabolically unfit in the coming years if they sit too much, thereby limiting the normally high volume of intermittent nonexercise physical activity in everyday life.

TL;DR: It is time to consider excessive sitting a serious health hazard, with the potential for ultimately giving consideration to the inclusion of too much sitting (or too few breaks from sitting) in physical activity and health guidelines.

TL;DR: The most powerful process known to regulate lipoprotein lipase protein and activity in muscle capillaries may be initiated by inhibitory signals during physical inactivity, independent of changes in lipop protein lipase messenger RNA.

TL;DR: One day of sitting considerably reduced insulin action; this effect was minimized, but not prevented, when energy intake was reduced to match expenditure.

TL;DR: Physical inactivity amplifies the ability of plasma lipids to suppress muscle LPL activity, and the light ambulatory contractions responsible for NEAT are sufficient for mitigating these deleterious effects.